Analytical Data
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基因名
BIRC6
- Application
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别名
BIRC6；KIAA1289；Baculoviral IAP repeat-containing Protein 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NR09
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BIRC6, also known as X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1, is a key member of the inhibitor of apoptosis protein (IAP) family that has garnered significant attention in cancer research and apoptosis regulation. The protein's primary function involves the inhibition of programmed cell death, a process crucial for maintaining cellular homeostasis and survival. Dysregulation of BIRC6 expression has been implicated in various cancers, where it may contribute to tumorigenesis by allowing cancer cells to evade apoptosis and resist chemotherapeutic agents. Recent studies have demonstrated that BIRC6 interacts with multiple signaling pathways, influencing cell proliferation and survival mechanisms, thus establishing itself as a potential therapeutic target. The production of recombinant BIRC6 protein allows researchers to investigate its functional properties, including its role in signal transduction and apoptosis inhibition. By elucidating the mechanisms underlying BIRC6's actions, scientists aim to better understand its contributions to cancer development and progression, paving the way for novel therapeutic strategies that can selectively target BIRC6 pathways to enhance the efficacy of existing cancer treatments. Additionally, the study of BIRC6 provides insights into the broader IAP family, enhancing our knowledge of apoptosis regulation and its implications for various diseases.
