Analytical Data
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Gene name
IFIH1
- Application
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Alternative Names
IFIH1；MDA5；RH116；Interferon-induced helicase C domain-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYX4
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Expression Region
700-1025aa
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AA Sequence
KLTKLRNTIMEQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVGVKAHHLIGAGHSSEFKPMTQNEQKEVISKFRTGKINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVAHSGSGVIEHETVNDFREKMMYKAIHCVQNMKPEEYAHKILELQMQSIMEKKMKTKRNIAKHYKNNPSLITFLCKNCSVLACSGEDIHVIEKMHHVNMTPEFKELYIVRENKALQKKCADYQINGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVVFKNNSTKKQYKKWVELPITFPNLDYSECCLFSDED
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Molecular Weight
41.5kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IFIH1, also known as interferon-inducible protein 1, plays a pivotal role in the innate immune response by recognizing viral RNA through its helicase domain, thereby activating the interferon pathway. Research into IFIH1 has gained significant attention due to its association with various autoimmune diseases, particularly type 1 diabetes and systemic lupus erythematosus, where genetic variations in the IFIH1 gene have been linked to increased susceptibility. The recombinant IFIH1 protein is utilized in studying its functional properties, signaling mechanisms, and interactions with other cellular components. Understanding the structure and activity of this protein can provide insights into its role in the antiviral response and autoimmune pathogenesis. Furthermore, recombinant IFIH1 serves as a valuable tool for developing therapeutic strategies aimed at modulating immune responses, making it a focal point of study in immunology and infectious disease research.
