Analytical Data
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基因名
UBASH3A
- Application
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别名
Cbl interacting Protein 4; Cbl-interacting Protein 4; CLIP4; STS 2; STS-2; Suppressor of T cell receptor signaling 2; Suppressor of T-cell receptor signaling 2; T cell ubiquitin ligand; T cell ubiquitin ligand Protein; T-cell ubiquitin ligand 1; TULA; TULA-1; UBASH3A; ubiquitin associated and SH3 domain containing. A; Ubiquitin-associated and SH3 domain-containing Protein A; UBS3A_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P57075
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表达区间
1-661 aa
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氨基酸序列
MAAGETQLYA KVSNKLKSRS SPSLLEPLLA MGFPVHTALK ALAATGRKTA EEALAWLHDH CNDPSLDDPI PQEYALFLCP TGPLLEKLQE FWRESKRQCA KNRAHEVFPH VTLCDFFTCE DQKVECLYEA LKRAGDRLLG SFPTAVPLAL HSSISYLGFF VSGSPADVIR EFAMTFATEA SLLAGTSVSR FWIFSQVPGH GPNLRLSNLT RASFVSHYIL QKYCSVKPCT KQLHLTLAHK FYPHHQRTLE QLARAIPLGH SCQWTAALYS RDMRFVHYQT LRALFQYKPQ NVDELTLSPG DYIFVDPTQQ DEASEGWVIG ISQRTGCRGF LPENYTDRAS ESDTWVKHRM YTFSLATDLN SRKDGEASSR CSGEFLPQTA RSLSSLQALQ ATVARKSVLV VRHGERVDQI FGKAWLQQCS TPDGKYYRPD LNFPCSLPRR SRGIKDFEND PPLSSCGIFQ SRIAGDALLD SGIRISSVFA SPALRCVQTA KLILEELKLE KKIKIRVEPG IFEWTKWEAG KTTPTLMSLE ELKEANFNID TDYRPAFPLS ALMPAESYQE YMDRCTASMV QIVNTCPQDT GVILIVSHGS TLDSCTRPLL GLPPRECGDF AQLVRKIPSL GMCFCEENKE EGKWELVNPP VKTLTHGANA AFNWRNWISG N
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分子量
74.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBASH3A is a pivotal protein that plays a crucial role in regulating immune responses and synaptic signaling by modulating the activity of various signaling pathways. It belongs to the UBA (ubiquitin-associated) and SH3 (SRC homology 3) domain-containing family of proteins, which are known for their involvement in protein-protein interactions and signal transduction. Research has indicated that UBASH3A may have implications in neural development and function, as well as in the pathophysiology of conditions such as autism spectrum disorders and schizophrenia. Its ability to regulate the deubiquitination processes and modulate the turnover of proteins makes it a significant target for therapeutic interventions. Recent studies have focused on elucidating its structural characteristics and functional mechanisms, revealing that UBASH3A interacts with a variety of proteins involved in receptor signaling and immune system regulation. Understanding UBASH3A's role in these processes could provide insights into the molecular underpinnings of neurodevelopmental disorders and other diseases linked to dysregulated immune responses. Therefore, the research of UBASH3A, particularly in the context of its recombinant protein forms, represents a promising frontier in both basic science and therapeutic development. By producing and studying UBASH3A as a recombinant protein, researchers aim to explore its functions in greater detail, investigate potential therapeutic applications, and further unravel its implications in health and disease.
