Analytical Data
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基因名
LMNB1
- Application
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别名
LMNB1；LMN2；LMNB；Lamin-B1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20700
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表达区间
2-583aa
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氨基酸序列
ATATPVPPR MGSRAGGPTT PLSPTRLSRL QEKEELRELN DRLAVYIDKV RSLETENSAL QLQVTEREEV RGRELTGLKA LYETELADAR RALDDTARER AKLQIELGKC KAEHDQLLLN YAKKESDLNG AQIKLREYEA ALNSKDAALA TALGDKKSLE GDLEDLKDQI AQLEASLAAA KKQLADETLL KVDLENRCQS LTEDLEFRKS MYEEEINETR RKHETRLVEV DSGRQIEYEY KLAQALHEMR EQHDAQVRLY KEELEQTYHA KLENARLSSE MNTSTVNSAR EELMESRMRI ESLSSQLSNL QKESRACLER IQELEDLLAK EKDNSRRMLT DKEREMAEIR DQMQQQLNDY EQLLDVKLAL DMEISAYRKL LEGEEERLKL SPSPSSRVTV SRASSSRSVR TTRGKRKRVD VEESEASSSV SISHSASATG NVCIEEIDVD GKFIRLKNTS EQDQPMGGWE MIRKIGDTSV SYKYTSRYVL KAGQTVTIWA ANAGVTASPP TDLIWKNQNS WGTGEDVKVI LKNSQGEEVA QRSTVFKTTI PEEEEEEEEA AGVVVEEELF HQQGTPRASN RSC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LMNB1 (Lamin B1) is a crucial protein that plays a significant role in maintaining the structural integrity of the nuclear envelope and regulating gene expression. It is a member of the lamin protein family, which constitutes a key component of the nuclear lamina—a dense fibrillar network inside the nucleus. Recent studies have highlighted the importance of LMNB1 in various cellular processes, including cell division, DNA replication, and response to cellular stress. Mutations or abnormal expression of LMNB1 have been linked to various diseases, including muscular dystrophies and certain forms of cancer. Research into the recombinant expression of LMNB1 is aimed at understanding its functional properties and interactions within the nucleus. By producing LMNB1 in a controlled laboratory setting, scientists can study its structure, post-translational modifications, and binding partners, shedding light on its role in nuclear architecture and cellular function. This research not only elucidates the fundamental biology of LMNB1 but also holds potential for therapeutic applications, as understanding its mechanisms could help in the development of targeted interventions for diseases associated with lamin dysfunction. As the field of cell biology advances, the recombinant study of LMNB1 continues to be a pivotal area of investigation, offering insights that could bridge the gap between basic research and clinical applications.
