Analytical Data
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Gene name
TULP3
- Application
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Alternative Names
MGC45295; Tubby like Protein 3; Tubby related Protein 3; Tubby-like Protein 3; Tubby-related Protein 3; TUBL 3; TUBL3; TULP 3; TULP3; TULP3_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75386
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Expression Region
1-442 aa
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AA Sequence
MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY PLCAVQAFGI GLSSFDSKLA CE
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Molecular Weight
49.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TULP3, a member of the TULP family of proteins, is crucial in the signaling pathways of photoreceptor cells in the retina. Understanding TULP3's role is essential because its dysfunction has been linked to retinal degenerative disorders, such as retinitis pigmentosa. Structural studies of TULP3, particularly its ability to bind to phosphoinositides, are crucial for elucidating its function in membrane trafficking and signaling. This research aims to explore the biochemical properties and structural features of TULP3 to better understand how it interacts with cellular membranes and signaling molecules. By characterizing the recombinant TULP3 protein, researchers strive to uncover the molecular mechanisms behind photoreceptor cell maintenance and survival. Ultimately, insights gleaned from TULP3 studies may pave the way for therapeutic strategies to combat retinal diseases, highlighting the protein's significance beyond basic biology to potential clinical applications.
