Analytical Data
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Gene name
FARSLA
- Application
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Alternative Names
FARSA; FARS; FARSL; FARSLA; Phenylalanine--tRNA ligase alpha subunit; EC 6.1.1.20; CML33; Phenylalanyl-tRNA synthetase alpha subunit; PheRS
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y285
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Expression Region
2-508aa
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AA Sequence
ADGQVAELLLRRLEASDGGLDSAELAAELGMEHQAVVGAVKSLQALGEVIEAELRSTKHWELTAEGEEIAREGSHEARVFRSIPPEGLAQSELMRLPSGKVGFSKAMSNKWIRVDKSAADGPRVFRVVDSMEDEVQRRLQLVRGGQAEKLGEKERSELRKRKLLAEVTLKTYWVSKGSAFSTSISKQETELSPEMISSGSWRDRPFKPYNFLAHGVLPDSGHLHPLLKVRSQFRQIFLEMGFTEMPTDNFIESSFWNFDALFQPQQHPARDQHDTFFLRDPAEALQLPMDYVQRVKRTHSQGGYGSQGYKYNWKLDEARKNLLRTHTTSASARALYRLAQKKPFTPVKYFSIDRVFRNETLDATHLAEFHQIEGVVADHGLTLGHLMGVLREFFTKLGITQLRFKPAYNPYTEPSMEVFSYHQGLKKWVEVGNSGVFRPEMLLPMGLPENVSVIAWGLSLERPTMIKYGINNIRELVGHKVNLQMVYDSPLCRLDAEPRPPPTQEAA
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Molecular Weight
73.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FARSLA (PhenylalanyltRNA Synthetase-Like Protein) is an intriguing protein involved in the critical processes of protein synthesis and amino acid metabolism. Research on FARSLA has emerged due to its potential roles in various physiological and pathological contexts, including its involvement in the regulation of gene expression and cellular stress response. Unlike typical aminoacyl-tRNA synthetases, FARSLA lacks a complete enzymatic function, prompting scientists to investigate its unique structural features and non-canonical functions. Recent studies have suggested that FARSLA may play a role in amino acid sensing and metabolic adaptation, particularly under stress conditions such as nutrient deprivation or oxidative stress. Additionally, FARSLA's association with cellular signaling pathways raises questions about its implications in diseases, including cancer, where metabolic reprogramming is a hallmark. Understanding the molecular mechanisms and interactions of FARSLA may provide new insights into metabolic disorders and therapeutic targets. The ongoing research focuses on elucidating its biological roles, structural dynamics, and potential applications in biotechnology and medicine, marking it as a significant area of interest in the fields of molecular biology and biochemistry.
