Analytical Data
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基因名
FARP2
- Application
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别名
FERM domain-including RhoGEF;FIR;FERM. RhoGEF and pleckstrin domain-containing protein 2;Pleckstrin homology domain-containing family C member 3;PH domain-containing family C member 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94887
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表达区间
44-324aa
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氨基酸序列
LHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWIWLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCADTTAALLTSHLLQSEIGDYDETLDREHLKVNEYLPGQQHCLEKILEFHQKHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLLD
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分子量
40.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FARP2 (FERM, ARHGEF, and Pleckstrin domain-containing protein 2) is a member of the FARP family of proteins that plays a crucial role in cellular signaling and is implicated in various physiological processes. Originally identified for its involvement in the regulation of small GTPases, particularly Rho and Rac, FARP2 is known to influence cytoskeletal dynamics, cell polarization, and motility. Research has increasingly focused on FARP2 due to its potential implications in pathological conditions, such as cancer progression and neurodevelopmental disorders. The protein's structure, featuring FERM and pleckstrin homology (PH) domains, suggests it plays multifaceted roles in membrane interactions and signal transduction pathways. Studies aiming to produce recombinant FARP2 protein have gained traction as they enable detailed investigations into its biochemical properties, interaction networks, and functional mechanisms. Furthermore, understanding FARP2's role in cell signaling can uncover novel therapeutic targets, potentially leading to advances in treatments for diseases associated with FARP2 dysregulation.
