Analytical Data
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Gene name
NTSR1
- Application
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Alternative Names
NTSR1；NTRR；Neurotensin receptor type 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P30989
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Expression Region
1-418aa
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AA Sequence
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
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Molecular Weight
47.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NTSR1, or Neurotensin Receptor 1, is a G protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes, including pain modulation, neuroendocrine regulation, and appetite control. Dysregulation of NTSR1 is implicated in several pathophysiological conditions, such as obesity, schizophrenia, and certain types of cancer, making it a compelling target for therapeutic interventions. The receptor is activated by neurotensin, a tridecapeptide, which binds to NTSR1 and triggers intracellular signaling pathways that influence cellular responses. Research into the recombinant expression and characterization of NTSR1 has gained momentum in recent years, driven by the need to elucidate its structure-function relationship and the mechanisms involved in its signaling. By producing NTSR1 as a recombinant protein, researchers can conduct detailed biophysical studies, screen for ligands, and design novel drugs that modulate its activity. Understanding the properties of NTSR1 at a molecular level is essential for developing targeted therapies that could alleviate the symptoms associated with NTSR1-related disorders. Additionally, the study of NTSR1 may also contribute to the broader understanding of GPCR biology, given the diverse functions and therapeutic potentials of this receptor family. As a result, NTSR1 continues to attract significant attention within the fields of pharmacology and neuroscience, highlighting its importance as a key player in both health and disease.
