Analytical Data
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基因名
AAT1
- Application
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别名
AAT1；AAT1；C3orf15；MAATS1；Cilia- and flagella-associated Protein 91
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P24298
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表达区间
2-496aa
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氨基酸序列
ASSTGDRSQAVRHGLRAKVLTLDGMNPRVRRVEYAVRGPIVQRALELEQELRQGVKKPFTEVIRANIGDAQAMGQRPITFLRQVLALCVNPDLLSSPNFPDDAKKRAERILQACGGHSLGAYSVSSGIQLIREDVARYIERRDGGIPADPNNVFLSTGASDAIVTVLKLLVAGEGHTRTGVLIPIPQYPLYSATLAELGAVQVDYYLDEERAWALDVAELHRALGQARDHCRPRALCVINPGNPTGQVQTRECIEAVIRFAFEERLFLLADEVYQDNVYAAGSQFHSFKKVLMEMGPPYAGQQELASFHSTSKGYMGECGFRGGYVEVVNMDAAVQQQMLKLMSVRLCPPVPGQALLDLVVSPPAPTDPSFAQFQAEKQAVLAELAAKAKLTEQVFNEAPGISCNPVQGAMYSFPRVQLPPRAVERAQELGLAPDMFFCLRLLEETGICVVPGSGFGQREGTYHFRMTILPPLEKLRLLLEKLSRFHAKFTLEYS
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分子量
56.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AAT1, or Alpha-1 Antitrypsin 1, is a key protein that plays a crucial role in protecting tissues from enzymatic damage caused by proteolytic enzymes, particularly in the lungs and liver. Deficiency or dysfunction of AAT1 is linked to various diseases, including chronic obstructive pulmonary disease (COPD) and liver cirrhosis. Given its significance in both genetic disorders and inflammatory conditions, research on AAT1 recombinant proteins has garnered increasing attention. The recombinant production of AAT1 offers the potential for therapeutic applications, such as replacement therapies for AAT deficiency and the development of novel treatments for related diseases. Advances in biotechnology have facilitated the generation and purification of AAT1 in heterologous systems, enabling detailed studies on its structure-function relationships and biological activity. Furthermore, understanding the mechanisms by which AAT1 interacts with other proteins and influences inflammatory pathways can provide insights into new therapeutic strategies. Overall, the exploration of AAT1 recombinant proteins is a promising avenue for improving clinical outcomes in patients with AAT-related health issues.
