Analytical Data
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Gene name
TRIM56
- Application
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Alternative Names
A130009K11Rik; DKFZp667O116; E3 ubiquitin-Protein ligase TRIM56; FLJ35608; Gm452; MGC37358; OTTMUSP00000027392; RING finger Protein 109; RNF109; TRI56_HUMAN; Trim56; Tripartite motif containing Protein 56; Tripartite motif-containing Protein 56
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BRZ2
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Expression Region
1-755 aa
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AA Sequence
MVSHGSSPSL LEALSSDFLA CKICLEQLRA PKTLPCLHTY CQDCLAQLAD GGRVRCPECR ETVPVPPEGV ASFKTNFFVN GLLDLVKARA CGDLRAGKPA CALCPLVGGT STGGPATARC LDCADDLCQA CADGHRCTRQ THTHRVVDLV GYRAGWYDEE ARERQAAQCP QHPGEALRFL CQPCSQLLCR ECRLDPHLDH PCLPLAEAVR ARRPGLEGLL AGVDNNLVEL EAARRVEKEA LARLREQAAR VGTQVEEAAE GVLRALLAQK QEVLGQLRAH VEAAEEAARE RLAELEGREQ VARAAAAFAR RVLSLGREAE ILSLEGAIAQ RLRQLQGCPW APGPAPCLLP QLELHPGLLD KNCHLLRLSF EEQQPQKDGG KDGAGTQGGE ESQSRREDEP KTERQGGVQP QAGDGAQTPK EEKAQTTREE GAQTLEEDRA QTPHEDGGPQ PHRGGRPNKK KKFKGRLKSI SREPSPALGP NLDGSGLLPR PIFYCSFPTR MPGDKRSPRI TGLCPFGPRE ILVADEQNRA LKRFSLNGDY KGTVPVPEGC SPCSVAALQS AVAFSASARL YLINPNGEVQ WRRALSLSQA SHAVAALPSG DRVAVSVAGH VEVYNMEGSL ATRFIPGGKA SRGLRALVFL TTSPQGHFVG SDWQQNSVVI CDGLGQVVGE YKGPGLHGCQ PGSVSVDKKG YIFLTLREVN KVVILDPKGS LLGDFLTAYH GLEKPRVTTM VDGRYLVVSL SNGTIHIFRV RSPDS
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Molecular Weight
81.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIM56, a member of the TRIM (tripartite motif-containing) protein family, plays a crucial role in various biological processes, including immune response, cell signaling, and antiviral defense. This protein is characterized by its RING (Really Interesting New Gene) domain, which is essential for its E3 ubiquitin ligase activity. Research has shown that TRIM56 is involved in the modulation of innate immune responses, particularly in the recognition and response to viral infections. It has been found to target various viral proteins for degradation, thus limiting viral replication and dissemination. Moreover, TRIM56 has been implicated in inflammatory processes and the regulation of cytokine signaling pathways, highlighting its potential role in autoimmune diseases and cancer. Given its multifaceted functions, understanding the mechanisms by which TRIM56 exerts its effects is of great interest. Current studies are focusing on the structural analysis and functional characterization of TRIM56, aiming to uncover its specific ligands and interactions within cellular pathways. The development of TRIM56 recombinant proteins is essential for these investigations, as they provide tools for elucidating the protein's role in cellular contexts and its potential as a therapeutic target. With increasing evidence supporting its significance in disease mechanisms, TRIM56 stands out as a promising candidate for further research, which may lead to novel strategies in combating viral infections and mitigating the effects of inflammatory diseases.
