Analytical Data
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Gene name
ZNF444
- Application
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Alternative Names
Endothelial zinc finger Protein 2; EZF 2; EZF-2; EZF2; FLJ11137; ZCCAN17; Zinc finger and SCAN domain-containing Protein 17; Zinc finger Protein 444; ZN444_HUMAN; ZNF444; ZSCAN17
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N0Y2
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Expression Region
1-326 aa
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AA Sequence
MEVAVPVKQEAEGLALDSPWHRFRRFHLGDAPGPREALGLLRALCRDWLRPEVHTKEQMLELLVLEQFLSALPADTQAWVCSRQPQSGEEAVALLEELWGPAASPDGSSATRVPQDVTQGPGATGGKEDSGMIPLGTAPGAEGPAPGDSQAVRPYKQEPSSPPLAPGLPAFLAAPGTTSCPECGKTSLKPAHLLRHRQSHSGEKPHACPECGKAFRRKEHLRRHRDTHPGSPGSPGPALRPLPAREKPHACCECGKTFYWREHLVRHRKTHSGARPFACWECGKGFGRREHVLRHQRIHGRAAASAQGAVAPGPDGGGPFPPWPLG
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Molecular Weight
61.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF444, a member of the zinc finger protein family, has garnered significant attention in the field of molecular biology due to its potential roles in gene regulation, cellular development, and disease pathogenesis. Research indicates that ZNF444 is involved in various cellular processes, including proliferation, differentiation, and apoptosis, making it a candidate for studying developmental biology and cancer. The ability of ZNF444 to interact with DNA and influence transcriptional activity positions it as a critical player in gene expression regulation. Additionally, emerging studies suggest a link between altered ZNF444 expression and various diseases, particularly certain types of cancer, where it may function as a tumor suppressor or an oncogene, depending on the context. The recombinant expression of ZNF444 enables researchers to investigate its functional properties, elucidate its molecular mechanisms, and explore its potential as a therapeutic target. Understanding the structural and functional attributes of ZNF444, combined with advances in recombinant protein technology, is expected to enhance our knowledge of its biological significance and its implications in health and disease. Furthermore, delving into the interactions of ZNF444 with other cellular proteins and its effects on downstream signaling pathways could pave the way for novel therapeutic strategies, particularly in personalized medicine approaches targeting gene regulation. Overall, the study of ZNF444, through the generation of recombinant proteins, represents a promising avenue for advancing our understanding of complex biological systems and developing innovative interventions in disease management.
