Analytical Data
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Gene name
TRIM58
- Application
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Alternative Names
BIA2; DKFZp434C091; Protein BIA2; TRI58_HUMAN; Trim58; Tripartite motif-containing Protein 58
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NG06
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Expression Region
1-486 aa
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AA Sequence
MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD VRDDHL
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Molecular Weight
54.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRIM58, a member of the tripartite motif (TRIM) protein family, plays a significant role in various cellular processes, including immune response, apoptosis, and cell cycle regulation. The TRIM family is characterized by a RING domain, one or two B-boxes, and a coiled-coil region, which enables them to mediate protein ubiquitination and regulate protein stability. Recent studies have implicated TRIM58 in the modulation of inflammatory responses and its potential links to various diseases, including cancer and autoimmune disorders. Research has revealed that TRIM58 can act as an E3 ubiquitin ligase, targeting specific substrates for ubiquitination and subsequent degradation, thus influencing various signaling pathways. Additionally, TRIM58 has been associated with the regulation of viral infections, suggesting its role in host-pathogen interactions. Understanding the mechanisms through which TRIM58 operates not only provides insights into its biological functions but also highlights its potential as a therapeutic target in diseases where these pathways are dysregulated. Given the increasing interest in the roles of E3 ubiquitin ligases in disease processes and their potential in drug discovery, TRIM58 represents a promising candidate for further research aimed at uncovering its full biological and clinical significance.
