Analytical Data
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基因名
CLDN1
- Application
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别名
CLDN1；CLD1；SEMP1；Claudin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95832
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表达区间
1-211aa
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氨基酸序列
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
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分子量
24.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLDN1, or Claudin-1, is a crucial component of tight junctions, which play a vital role in maintaining the integrity of epithelial and endothelial barriers. This protein regulates paracellular permeability, thereby influencing the movement of ions, solutes, and water between cells. Recent studies have highlighted the significance of CLDN1 in various physiological and pathological contexts, including its involvement in cell proliferation, differentiation, and apoptosis. Elevated expression of CLDN1 has been correlated with several cancers, where it can promote tumor invasion and metastasis by altering tight junction functionality. Additionally, CLDN1 serves as a potential target for therapeutic interventions, particularly in conditions where tight junction integrity is compromised. The recombinant expression of CLDN1 has enabled researchers to explore its structural and functional properties in detail, facilitating the development of antibodies and other biologics for potential clinical applications. Understanding the mechanisms governing CLDN1 function is critical for advancing our knowledge of barrier biology, cancer progression, and potential treatment strategies that could normalize tight junction dynamics in various diseases. As research progresses, the insights garnered from CLDN1 studies are expected to inform new therapeutic avenues and enhance our understanding of cell biology.
