Analytical Data
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基因名
APBB1IP
- Application
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别名
APBB1IP；KIAA1027；TLN；Talin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z5R6
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表达区间
1-666aa
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氨基酸序列
MGESSEDIDQ MFSTLLGEMD LLTQSLGVDT LPPPDPNPPR AEFNYSVGFK DLNESLNALE DQDLDALMAD LVADISEAEQ RTIQAQKESL QNQHHSASLQ ASIFSGAASL GYGTNVAATG ISQYEDDLPP PPADPVLDLP LPPPPPEPLS QEEEEAQAKA DKIKLALEKL KEAKVKKLVV KVHMNDNSTK SLMVDERQLA RDVLDNLFEK THCDCNVDWC LYEIYPELQI ERFFEDHENV VEVLSDWTRD TENKILFLEK EEKYAVFKNP QNFYLDNRGK KESKETNEKM NAKNKESLLE ESFCGTSIIV PELEGALYLK EDGKKSWKRR YFLLRASGIY YVPKGKTKTS RDLACFIQFE NVNIYYGTQH KMKYKAPTDY CFVLKHPQIQ KESQYIKYLC CDDTRTLNQW VMGIRIAKYG KTLYDNYQRA VAKAGLASRW TNLGTVNAAA PAQPSTGPKT GTTQPNGQIP QATHSVSAVL QEAQRHAETS KDKKPALGNH HDPAVPRAPH APKSSLPPPP PVRRSSDTSG SPATPLKAKG TGGGGLPAPP DDFLPPPPPP PPLDDPELPP PPPDFMEPPP DFVPPPPPSY AGIAGSELPP PPPPPPAPAP APVPDSARPP PAVAKRPPVP PKRQENPGHP GGAGGGEQDF MSDLMKALQK KRGNVS
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
APBB1IP (Amyloid Precursor Protein-Binding, Family B1, Interacting Protein) is a protein that has garnered interest due to its potential implications in neurodegenerative diseases, particularly Alzheimer’s disease. The protein is known to interact with the amyloid precursor protein (APP), which is crucial in the formation of amyloid-beta plaques, a hallmark of Alzheimer’s pathology. Understanding the role of APBB1IP in this context is vital, as it may influence APP processing and subsequent plaque formation. Additionally, APBB1IP is involved in cellular signaling pathways, suggesting it may play a broader role in neuronal function and health. Research on APBB1IP has expanded to explore its potential as a therapeutic target or biomarker for Alzheimer's disease and other neurodegenerative disorders. Studies involve the expression and characterization of recombinant APBB1IP to elucidate its functional dynamics, interactions with other proteins, and impact on cellular processes. The continued investigation of APBB1IP may provide insights into the molecular mechanisms underlying Alzheimer’s disease, offering pathways for the development of innovative treatment strategies. Overall, the study of APBB1IP represents a promising avenue in neurobiology, bridging molecular research with the pursuit of understanding complex neurological disorders.
