Analytical Data
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Gene name
TIGD6
- Application
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Alternative Names
TIGD6; Tigger transposable element-derived Protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q17RP2
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Expression Region
1-521 aa
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AA Sequence
MANKGNKKRR QFSLEEKMKV VGAVDSGKRK GDVAKEFGIT PSTLSTFLKD RTKFEEKVRE ASVGPQRKRM RSALYDDIDK AVFAWFQEIH AKNILVTGSV IRKKALNLAN MLGYDNFQAS VGWLNRFRDR HGIALKAVCR EDSDRLMNGL GIDKINEWHA GEIIKLIADY SPDDIFNADE TGVFFQLLPQ HTLAAKGDHC RGGKKAKQRL TALFCCNASG TEKMRPLIVG RSASPHCLKN IHSLPCDYRA NQWAWMTRDL FNEWLMQVDA RMKRAERRIL LLIDNCSAHN MLPHLERIQV GYLPSNCTAV LQPLNLGIIH TMKVLYQSHL LKQILLKLNS SEDQEEVDIK QAIDMIAAAW WSVKPSTVVK CWQKAGIVPM EFAECDTESA ASEPDIAIEK LWHTVAIATC VPNEVNFQDF VTADDDLIIS QDTDIIQDMV AGENTSEAGS EDEGEVSLPE QPKVTITEAI SSVQKLRQFL STCVDIPDAI FGQLNGIDEY LMKRVTQTLI DSKITDFLQT K
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Molecular Weight
58.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIGD6, a member of the T cell immunoglobulin and mucin domain (TIM) family, has garnered attention in immunological research due to its role in modulating immune responses. Initially identified in T cells, TIGD6 is thought to participate in the regulation of immune tolerance and inflammation, which are critical in the context of autoimmunity and allergic diseases. Its unique structure, characterized by immunoglobulin-like domains and mucin-like sequences, suggests potential interactions with various ligands and receptors, influencing cellular signaling pathways. The investigation of TIGD6 recombinant proteins has been pivotal in elucidating its functional properties, including its effects on T cell activation and regulatory processes. Recent studies have indicated that TIGD6 may play a role in promoting regulatory T cell differentiation, thereby providing insights into strategies for cancer immunotherapy and treatments for autoimmune conditions. The recombinant expression of TIGD6 allows for detailed biochemical characterization and functional assays, facilitating a deeper understanding of its mechanisms in immune regulation. As research progresses, the potential therapeutic implications of targeting TIGD6 warrant further exploration, aiming to harness its modulatory effects to develop innovative approaches for manipulating immune responses in various diseases.
