Analytical Data
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Gene name
APBB3
- Application
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Alternative Names
APBB3；FE65L2；Amyloid-beta A4 precursor Protein-binding family B member 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95704
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Expression Region
1-486aa
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AA Sequence
MLGKDYMLAI ILVNCDDDLW GDHSLEVEAG LPPGWRKIHD AAGTYYWHVP SGSTQWQRPT WELGDAEDPG TGTEGIWGLR PPKGRSFSSL ESSLDRSNSL SWYGGESYIQ SMEPGAKCFA VRSLGWVEVP EEDLAPGKSS IAVNNCIQQL AQTRSRSQPP DGAWGEGQNM LMILKKDAMS LVNPLDHSLI HCQPLVHIRV WGVGSSKGRD RDFAFVASDK DSCMLKCHVF CCDVPAKAIA SALHGLCAQI LSERVEVSGD ASCCSPDPIS PEDLPRQVEL LDAVSQAAQK YEALYMGTLP VTKAMGMDVL NEAIGTLTAR GDRNAWVPTM LSVSDSLMTA HPIQAEASTE EEPLWQCPVR LVTFIGVGRD PHTFGLIADL GRQSFQCAAF WCQPHAGGLS EAVQAACMVQ YQKCLVASAA RGKAWGAQAR ARLRLKRTSS MDSPGGPLPL PLLKGGVGGA GATPRKRGVF SFLDAFRLKP SLLHMP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
APBB3 (Amyloid Precursor Protein-Binding Protein 3) is a member of the APBB family, which has garnered significant attention due to its involvement in various cellular processes, including synaptic function and Alzheimer’s disease pathology. Research indicates that APBB3 interacts with the amyloid precursor protein (APP), potentially influencing amyloid-beta peptide production, a key player in Alzheimer's disease. Understanding the structure and function of APBB3 is crucial for elucidating its role in neuronal health and disease. Recent studies have pointed to its potential involvement in synaptic signaling and cell adhesion, suggesting that it may play a pivotal role in neuronal communication and plasticity. With the growing emphasis on targeting protein interactions as therapeutic strategies for neurodegenerative diseases, studying the recombinant APBB3 protein has become increasingly relevant. By investigating its properties and interactions, researchers aim to uncover novel insights into the molecular mechanisms underlying Alzheimer's disease and to identify potential therapeutic targets. The recombinant form of APBB3 allows for detailed exploration of its biochemical properties and functional roles within neuronal cells, thus providing a valuable tool for advancing our understanding of both normal brain function and the pathological changes associated with neurodegeneration. As research progresses, the implications of APBB3 in both health and disease continue to be a promising frontier in neuroscience.
