Analytical Data
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基因名
EIF2A
- Application
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别名
EIF2A. CDA02. MSTP004. MSTP089
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BY44
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表达区间
1-585aa
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氨基酸序列
MAPSTPLLTV RGSEGLYMVN GPPHFTESTV FPRESGKNCK VCIFSKDGTL FAWGNGEKVN IISVTNKGLL HSFDLLKAVC LEFSPKNTVL ATWQPYTTSK DGTAGIPNLQ LYDVKTGTCL KSFIQKKMQN WCPSWSEDET LCARNVNNEV HFFENNNFNT IANKLHLQKI NDFVLSPGPQ PYKVAVYVPG SKGAPSFVRL YQYPNFAGPH AALANKSFFK ADKVTMLWNK KATAVLVIAS TDVDKTGASY YGEQTLHYIA TNGESAVVQL PKNGPIYDVV WNSSSTEFCA VYGFMPAKAT IFNLKCDPVF DFGTGPRNAA YYSPHGHILV LAGFGNLRGQ MEVWDVKNYK LISKPVASDS TYFAWCPDGE HILTATCAPR LRVNNGYKIW HYTGSILHKY DVPSNAELWQ VSWQPFLDGI FPAKTITYQA VPSEVPNEEP KVATAYRPPA LRNKPITNSK LHEEEPPQNM KPQSGNDKPL SKTALKNQRK HEAKKAAKQE ARSDKSPDLA PTPAPQSTPR NTVSQSISGD PEIDKKIKNL KKKLKAIEQL KEQAATGKQL EKNQLEKIQK ETALLQELED LELGI
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分子量
64.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of EIF2A, or eukaryotic translation initiation factor 2A, has gained significant attention due to its critical role in the initiation of translation, a fundamental process for protein synthesis in eukaryotic cells. EIF2A is pivotal in the formation of the translation initiation complex, facilitating the binding of the initiator tRNA to the ribosome in a GTP-dependent manner. Research has shown that EIF2A is not only essential for normal cellular function but also plays a significant role in cellular responses to stress, such as starvation and viral infection, where it helps to modulate protein synthesis and maintain cellular homeostasis. Furthermore, alterations in EIF2A activity are implicated in various diseases, including cancer and neurodegenerative disorders, which underscores its potential as a therapeutic target. Recent advances in genetic and biochemical methods have enabled the generation of recombinant EIF2A proteins, allowing researchers to study its structure and function in greater detail. The characterization of these recombinant proteins aids in elucidating the molecular mechanisms underlying translation initiation and stress response pathways. Overall, the investigation of EIF2A and its recombinant forms is crucial for understanding the intricacies of translation regulation and its implications in health and disease, paving the way for novel therapeutic strategies.
