Analytical Data
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Gene name
TFCP2L3
- Application
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Alternative Names
BOM; Brother of mammalian grainyhead; Deafness autosomal dominant 28; DFNA28; ECTDS; FLJ11172; FLJ13782; Grainyhead like 2 (Drosophila); Grainyhead like 2; Grainyhead like Protein 2 homolog; Grainyhead like transcription factor 2; Grainyhead-like Protein 2 homolog; GRHL 2; GRHL2; GRHL2_HUMAN; MGC149294; MGC149295; RGD1561191; TFCP2L3; Transcription factor CP2 like 3; Transcription factor CP2-like 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6ISB3
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Expression Region
1-625 aa
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AA Sequence
MSQESDNNKR LVALVPMPSD PPFNTRRAYT SEDEAWKSYL ENPLTAATKA MMSINGDEDS AAALGLLYDY YKVPRDKRLL SVSKASDSQE DQEKRNCLGT SEAQSNLSGG ENRVQVLKTV PVNLSLNQDH LENSKREQYS ISFPESSAII PVSGITVVKA EDFTPVFMAP PVHYPRGDGE EQRVVIFEQT QYDVPSLATH SAYLKDDQRS TPDSTYSESF KDAATEKFRS ASVGAEEYMY DQTSSGTFQY TLEATKSLRQ KQGEGPMTYL NKGQFYAITL SETGDNKCFR HPISKVRSVV MVVFSEDKNR DEQLKYWKYW HSRQHTAKQR VLDIADYKES FNTIGNIEEI AYNAVSFTWD VNEEAKIFIT VNCLSTDFSS QKGVKGLPLM IQIDTYSYNN RSNKPIHRAY CQIKVFCDKG AERKIRDEER KQNRKKGKGQ ASQTQCNSSS DGKLAAIPLQ KKSDITYFKT MPDLHSQPVL FIPDVHFANL QRTGQVYYNT DDEREGGSVL VKRMFRPMEE EFGPVPSKQM KEEGTKRVLL YVRKETDDVF DALMLKSPTV KGLMEAISEK YGLPVEKIAK LYKKSKKGIL VNMDDNIIEH YSNEDTFILN MESMVEGFKV TLMEI
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Molecular Weight
71.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TFCP2L3, a member of the TFCP2 family of transcription factors, has garnered significant interest in recent years due to its critical roles in various biological processes, including embryonic development, pluripotency maintenance, and cellular differentiation. Research has shown that TFCP2L3 is involved in regulating gene expression patterns essential for stem cell self-renewal and the transition to differentiation, making it a pivotal factor in developmental biology and regenerative medicine. Moreover, its involvement in key signaling pathways suggests that TFCP2L3 may also play a role in various disease states, including cancer. Studies investigating the recombination and expression of TFCP2L3 protein have become increasingly important for elucidating its functional mechanisms and understanding its interactions with other cellular components. By generating recombinant TFCP2L3, researchers aim to explore its structural properties, binding affinities to DNA, and interactions with other transcriptional regulators. This foundational knowledge can potentially lead to targeted therapeutic strategies, especially in diseases where TFCP2L3 expression is dysregulated. Understanding the full scope of TFCP2L3’s functions will enhance our comprehension of not only stem cell biology but also the molecular underpinnings of many disorders, thereby opening new avenues for intervention.
