Analytical Data
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基因名
EBI2
- Application
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别名
GPR183; EBI2; G-protein coupled receptor 183; Epstein-Barr virus-induced G-protein coupled receptor 2; EBV-induced G-protein coupled receptor 2; hEBI2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32249
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表达区间
1-361aa
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氨基酸序列
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
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分子量
65.45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EBI2, or Epstein-Barr virus-induced gene 2, is a G protein-coupled receptor (GPCR) that plays a significant role in the immune system, particularly in regulating B cell development and migration. Research into EBI2 has gained prominence due to its involvement in various immune responses and its potential implications in autoimmune diseases and cancer. EBI2 facilitates the positioning of B cells within germinal centers, where they undergo affinity maturation and differentiation. Misregulation of EBI2 signaling has been linked to improper B cell activation and the development of lymphoid malignancies. The study of EBI2 recombinant proteins has become essential for understanding the receptor's structure-function relationships, its downstream signaling pathways, and its potential as a therapeutic target. By generating and characterizing EBI2 recombinant proteins, researchers aim to elucidate the molecular mechanisms by which EBI2 influences immune cell behavior, ultimately leading to the identification of novel intervention strategies for immune-related disorders. This ongoing research not only contributes to our understanding of basic immunology but also holds promise for advancing targeted therapies in the treatment of diseases associated with B cell dysregulation.
