Analytical Data
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Gene name
ZBTB3
- Application
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Alternative Names
Zbtb3; ZBTB3_HUMAN; Zinc finger and BTB domain containing Protein 3; Zinc finger and BTB domain-containing Protein 3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H5J0
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Expression Region
1-574 aa
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AA Sequence
MLREFSKWGVEASPGKAWERKRSLLRGAVGRYRGATGGDLFWAPFPSWGTMEFPEHSQQLLQSLREQRSQGFLCDCTVMVGSTQFLAHRAVLASCSPFFQLFYKERELDKRDLVCIHNEIVTAPAFGLLLDFMYAGQLTLRGDTPVEDVLAAASYLHMNDIVKVCKRRLQARALAEADSTKKEEETNSQLPSLEFLSSTSRGTQPSLASAETSGHWGKGEWKGSAAPSPTVRPPDEPPMSSGADTTQPGMEVDAPHLRAPHPPVADVSLASPSSSTETIPTNYFSSGISAVSLEPLPSLDVGPESLRVVEPKDPGGPLQGFYPPASAPTSAPAPVSAPVPSQAPAPAEAELVQVKVEAIVISDEETDVSDEQPQGPERAFPSGGAVYGAQPSQPEAFEDPGAAGLEEVGPSDHFLPTDPHLPYHLLPGAGQYHRGLVTSPLPAPASLHEPLYLSSEYEAAPGSFGVFTEDVPTCKTCGKTFSCSYTLRRHATVHTRERPYECRYCLRSYTQSGDLYRHIRKAHNEDLAKRSKPDPEVGPLLGVQPLPGSPTADRQSSSGGGPPKDFVLAPKTNI
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Molecular Weight
88.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZBTB3, a member of the zinc finger and BTB/POZ domain-containing protein family, has garnered attention due to its regulatory role in gene expression and potential implications in cancer biology. Studies have indicated that ZBTB3 can influence various cellular processes by interacting with transcription factors and modulating chromatin structure. Its expression is often found to be altered in several types of cancers, suggesting a pivotal role in tumorigenesis. Researchers are particularly interested in ZBTB3 as a potential biomarker for cancer diagnosis and as a therapeutic target. The recombinant expression of ZBTB3 protein allows for detailed structural and functional studies, enabling the exploration of its mechanisms of action in normal and pathological states. By generating a stable recombinant form of ZBTB3, scientists aim to elucidate its interactions with other proteins, its impact on transcriptional regulation, and its downstream effects on cell proliferation and differentiation. Such studies could provide insights into the molecular pathways involved in cancer progression and might pave the way for the development of novel therapeutic strategies. Additionally, understanding the functional domains and regulatory mechanisms of ZBTB3 may open new avenues for targeted therapy, thus highlighting its significance in ongoing cancer research.
