Analytical Data
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Gene name
DYX1C1
- Application
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Alternative Names
Dyslexia susceptibility 1 candidate 1; Dyslexia susceptibility 1 candidate gene 1 protein; DYX1; DYX1C1; DYXC1; DYXC1_HUMAN; EKN1; FLJ37882; MGC70618; RD
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WXU2
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Expression Region
1-381aa
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AA Sequence
MPLQVSDYSWQQTKTAVFLSLPLKGVCVRDTDVFCTENYLKVNFPPFLFEAFLYAPIDDESSKAKIGNDTIVFTLYKKEAAMWETLSVTGVDKEMMQRIREKSILQAQERAKEATEAKAAAKREDQKYALSVMMKIEEEERKKIEDMKENERIKATKALEAWKEYQRKAEEQKKIQREEKLCQKEKQIKEGRKKIKYKSLTRNLASRNLAPKGRNSENIFTEKLKEDSIPAPRSVGSIKINFTPRVFPTALRESQVAEEEEWLHKQAEARRAMNTDIAELCDLKEEEKNPEWLKDKGNKLFATENYLAAINAYNLAIRLNNKMPLLYLNRAVCHLKLKNLHKAIEDSSKEFCSLEGIECQASEPKLSHHIPSDLHVYIQMA
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Molecular Weight
70.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DYX1C1 is a gene that has garnered significant attention in the field of neuroscience and genetics due to its association with developmental dyslexia, a common learning disorder affecting reading and language processing. The gene encodes a protein involved in various cellular processes, including neuronal migration and axonogenesis, suggesting its critical role in brain development. Dysregulation of DYX1C1 has been linked to impairments in these processes, potentially contributing to the neural deficits observed in dyslexia patients. This has spurred research into the functional characterization of DYX1C1, with efforts to produce recombinant DYX1C1 protein to facilitate studies on its biochemical properties and interactions with other cellular molecules. Understanding the structure and function of DYX1C1 at a molecular level may provide insights into the pathophysiology of dyslexia and inform the development of therapeutic strategies. The recombinant protein can be utilized in various assays to investigate its role in neuronal function and its potential implications in neurodevelopmental disorders. As research progresses, elucidating the mechanisms by which DYX1C1 influences cognitive functions may also contribute to broader understandings of genetic contributions to learning disabilities.
