Analytical Data
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基因名
TCEB3C
- Application
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别名
ELOA3; TCEB3C; TCEB3L2Elongin-A3; EloA3; RNA polymerase II transcription factor SIII subunit A3; Transcription elongation factor B polypeptide 3C
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NG57
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表达区间
1-546 aa
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氨基酸序列
MAAGSTTLRA VGKLQVRLAT KTEPKKLEKY LQKLSALPMT ADILAETGIR KTVKRLRKHQ HVGDFARDLA ARWKKLVLVD RNTGPDPQDP EESASRQRFG EALQEREKAW GFPENATAPR SPSHSPEHRR TARRTPPGQQ RPHPRSPSRE PRAERKRPRM APADSGPHRD PPTRTAPLPM PEGPEPAVPG EQPGRGHAHA AQGGPLLGQG CQGQPQGEAV GSHSKGHKSS RGASAQKSPP VQESQSERLQ AAGADSAGPK TVPSHVFSEL WDPSEAWMQA NYDLLSAFEA MTSQANPEAL SAPALQEEAA FPGRRVNAKM PVYSGSRPAC QLQVPTLRQQ CLRVPRNNPD ALGDVEGVPY SVLEPVLEGW TPDQLYRTEK DNAALARETD ELWRIHCLQD FKEEKPQEHE SWRELYLRLR DAREQRLRVV TTKIRSAREN KPSGRQTKMI CFNSVAKTPY DASRRQEKSA GAADPGNGEM EPAPKPAGSS QAPSGLGDGD GGSVSGGGSS NRHAAPADKT RKQAAKKVAP LMAKAIRDYK GRFSRR
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分子量
60.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCEB3C, or TCEB3C Protein, is a crucial component of the transcriptional machinery in cells, playing a significant role in RNA polymerase II transcription initiation and regulation. Its primary function involves the interaction with various transcription factors and co-factors, facilitating the proper assembly of the transcriptional complex. Research into TCEB3C has gained momentum due to its implications in various cellular processes, including cell growth, differentiation, and response to stress. Abnormalities in TCEB3C function have been linked to several diseases, including certain cancers, highlighting its potential as a therapeutic target. Understanding the structure, stability, and interaction mechanisms of TCEB3C is essential for elucidating its role in transcription regulation and developing strategies for modulating its activity in disease contexts. Recent studies using advanced techniques such as X-ray crystallography and cryo-electron microscopy have provided insights into the protein’s functional domains and how they regulate transcription. This growing body of knowledge not only enhances our understanding of TCEB3C but also opens new avenues for therapeutic interventions by targeting its pathways in disease progression and treatment.
