Analytical Data
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基因名
TCEB2
- Application
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别名
EloB; ELOB_HUMAN; Elongin 18 kDa subunit; Elongin B; Elongin-B; RNA polymerase II transcription factor SIII p18 subunit; RNA polymerase II transcription factor SIII subunit B; SIII; SIII p18; TCEB 2; Tceb2; Transcription elongation factor B (SIII) polypeptide 2; Transcription elongation factor B polypeptide 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15370
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表达区间
1-118 aa
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氨基酸序列
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQ
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分子量
38.72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TCEB2, also known as Transcription Elongation Factor B polypeptide 2, plays a crucial role in the regulation of gene expression by facilitating the transcription elongation process. Its function is essential for the proper synthesis of mRNA and has been implicated in various biological processes, including cellular differentiation and proliferation. Research into TCEB2 has gained attention due to its potential connections to several diseases, particularly cancer, where aberrations in transcriptional regulation are a hallmark. Understanding the molecular mechanisms by which TCEB2 operates can provide insights into how transcriptional dysregulation occurs in oncogenesis. Additionally, TCEB2's interactions with other transcription factors and its role in the phosphorylation of RNA polymerase II highlight its significance in the transcription machinery. Furthermore, studies on recombinant TCEB2 protein production can aid in identifying novel therapeutic targets and strategies for modulating its activity, thereby contributing to cancer therapy and other disorders linked to transcriptional dysregulation. Overall, TCEB2's pivotal function in transcription makes it a focal point for research in molecular biology and medicine, with the potential to uncover new avenues for targeted treatments.
