Analytical Data
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基因名
DTX3
- Application
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别名
Deltex3; Dtx3; DTX3_HUMAN; Protein deltex 3; Protein deltex-3; RING finger protein 154; RNF154
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N9I9
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表达区间
1-347aa
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氨基酸序列
MSFVLSRMAA CGGTCKNKVT VSKPVWDFLS KETPARLARL REEHRVSILI DGETSDIYVL QLSPQGPPPA PPNGLYLARK ALKGLLKEAE KELKKAQRQG ELMGCLALGG GGEHPEMHRA GPPPLRAAPL LPPGARGLPP PPPPLPPPLP PRLREEAEEQ ESTCPICLGE IQNAKTLEKC RHSFCEGCIT RALQVKKACP MCGRFYGQLV GNQPQNGRML VSKDATLLLP SYEKYGTIVI QYVFPPGVQG AEHPNPGVRY PGTTRVAYLP DCPEGNKVLT LFRKAFDQRL TFTIGTSMTT GRPNVITWND IHHKTSCTGG PQLFGYPDPT YLTRVQEELR AKGITDD
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分子量
37.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DTX3 (Deltex Homolog 3) is a member of the Deltex family of proteins, which plays a crucial role in Notch signaling, a fundamental pathway involved in cell differentiation, proliferation, and fate determination. Research into DTX3 has gained attention due to its potential implications in various biological processes and diseases, particularly in cancer and developmental disorders. Unlike its well-studied counterparts, DTX1 and DTX2, DTX3's functions remain less understood, prompting investigations into its mechanisms of action and interactions with other cellular factors. Recent studies have indicated that DTX3 may be involved in the regulation of gene expression and has been linked to the modulation of immune responses. Additionally, the characterization of DTX3 as a recombinant protein allows scientists to explore its structural properties and functional dimensions in vitro, enabling insights into its roles at the molecular level. Understanding the biological significance of DTX3 is critical, as it may reveal novel therapeutic targets and strategies for diseases where Notch signaling is disrupted. Thus, ongoing research focused on the recombinant expression and functional characterization of DTX3 is essential for elucidating its contributions to cell biology and disease pathology.
