Analytical Data
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Gene name
WTIP
- Application
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Alternative Names
WTIP; Wilms tumor Protein 1-interacting Protein; WT1-interacting Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
A6NIX2
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Expression Region
1-430 aa
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AA Sequence
MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL
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Molecular Weight
73.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WTIP (Wilm's Tumor 1-associating Protein) is a protein that has garnered significant attention in recent years due to its involvement in various cellular processes, including cell proliferation, differentiation, and survival. It is particularly noted for its role in the development and progression of certain cancers, making it a potential target for therapeutic interventions. Research has shown that WTIP interacts with critical signaling pathways, such as the Hippo-YAP pathway, which regulates organ size and tissue homeostasis. Dysregulation of this pathway is implicated in tumorigenesis, suggesting that understanding WTIP's structural and functional properties could offer insights into cancer mechanisms. Additionally, WTIP has been explored in the context of various diseases, including its role in renal pathology and its involvement in embryonic development. The study of WTIP as a recombinant protein allows researchers to investigate its molecular characteristics, interactions, and potential applications in drug development. As such, the ongoing research surrounding WTIP aims to elucidate its biological functions and therapeutic potential, paving the way for novel strategies in cancer treatment and regenerative medicine.
