Analytical Data
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基因名
TBC1D21
- Application
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别名
TBC1D21; TBC1 domain family member 21
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IYX1
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表达区间
1-336 aa
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氨基酸序列
MTTLSPENSL SARQSASFIL VKRKPPIDKT EWDSFFDESG HLAKSRDFIC VNILERGLHP FVRTEAWKFL TGYFSWQSSQ DERLTVDSMR RKNYKALCQM YEKIQPLLEN LHRNFTETRN NIARDIQKIY DKDPLGNVLI DKKRLEKILL LSYVCNTQAE YQQGFHEMMM LFQLMVEHDH ETFWLFQFFL QKTEHSCVIN IGVAKNLDML STLITFLDPV FAEHLKGKGA GAVQSLFPWF CFCFQRAFKS FDDVWRLWEV LLTGKPCRNF QVLVAYSMLQ MVREQVLQES MGGDDILLAC NNLIDLDADE LISAACVVYA ELIQKDVPQT LKDFFL
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分子量
39.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D21, a member of the TBC (Tre-2/Bub2/Cdc16) domain-containing protein family, has garnered interest in recent years due to its role in regulating cellular processes, particularly those related to endosomal trafficking and autophagy. The TBC1D21 gene is implicated in modulating the Rab GTPase activity, which is crucial for membrane trafficking pathways. Recent studies have suggested that TBC1D21 may play a pivotal role in the homeostasis of cellular organelles and may influence various cellular responses to stress. Its involvement in mediating intracellular communication and protein transport makes it a critical focus for understanding diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Researchers are increasingly exploring the potential of TBC1D21 as a therapeutic target, either by directly modulating its activity or by influencing its interactions with Rab proteins. Additionally, investigations into the structural properties of TBC1D21 and its recombinant forms aim to elucidate its biochemical functions and regulatory mechanisms. Overall, the study of TBC1D21 and its recombinant protein holds promise for revealing novel insights into cellular dynamics and developing innovative strategies to address associated pathologies.
