Analytical Data
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Gene name
TBC1D22A
- Application
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Alternative Names
TBC1D22A; C22orf4; TBC1 domain family member 22A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WUA7
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Expression Region
1-517 aa
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AA Sequence
MASDGARKQF WKRSNSKLPG SIQHVYGAQH PPFDPLLHGT LLRSTAKMPT TPVKAKRVST FQEFESNTSD AWDAGEDDDE LLAMAAESLN SEVVMETANR VLRNHSQRQG RPTLQEGPGL QQKPRPEAEP PSPPSGDLRL VKSVSESHTS CPAESASDAA PLQRSQSLPH SATVTLGGTS DPSTLSSSAL SEREASRLDK FKQLLAGPNT DLEELRRLSW SGIPKPVRPM TWKLLSGYLP ANVDRRPATL QRKQKEYFAF IEHYYDSRND EVHQDTYRQI HIDIPRMSPE ALILQPKVTE IFERILFIWA IRHPASGYVQ GINDLVTPFF VVFICEYIEA EEVDTVDVSG VPAEVLCNIE ADTYWCMSKL LDGIQDNYTF AQPGIQMKVK MLEELVSRID EQVHRHLDQH EVRYLQFAFR WMNNLLMREV PLRCTIRLWD TYQSEPDGFS HFHLYVCAAF LVRWRKEILE EKDFQELLLF LQNLPTAHWD DEDISLLLAE AYRLKFAFAD APNHYKK
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Molecular Weight
59.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBC1D22A is a member of the TBC (Tre-2/Bub2/CDC16) domain-containing protein family, which plays a crucial role in regulating intracellular trafficking and cellular signaling. It has been implicated in various biological processes, including endosomal dynamics, cytoskeletal organization, and cell motility, making it a significant focus of research in cell biology and molecular medicine. Recent studies indicate that TBC1D22A may be involved in the modulation of small GTPase activity, particularly Rab proteins, which are essential for vesicle transport and membrane fusion. Abnormalities in TBC1D22A expression or function have been linked to several diseases, including cancer, neurodegenerative disorders, and infectious diseases, highlighting its potential as a therapeutic target. The characterization of recombinant TBC1D22A protein can provide valuable insights into its structure-function relationships, facilitate the identification of interacting partners, and elucidate the molecular mechanisms underlying its role in pathological conditions. Consequently, the generation of TBC1D22A recombinant proteins and the study of their functional properties is essential for advancing our understanding of cellular processes influenced by this protein and developing novel therapeutic strategies.
