Analytical Data
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Gene name
WSB1
- Application
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Alternative Names
WSB1; SWIP1; WD repeat and SOCS box-containing Protein 1; WSB-1; SOCS box-containing WD Protein SWiP-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6I7
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Expression Region
1-421 aa
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AA Sequence
MASFPPRVNE KEIVRLRTIG ELLAPAAPFD KKCGRENWTV AFAPDGSYFA WSQGHRTVKL VPWSQCLQNF LLHGTKNVTN SSSLRLPRQN SDGGQKNKPR EHIIDCGDIV WSLAFGSSVP EKQSRCVNIE WHRFRFGQDQ LLLATGLNNG RIKIWDVYTG KLLLNLVDHT EVVRDLTFAP DGSLILVSAS RDKTLRVWDL KDDGNMMKVL RGHQNWVYSC AFSPDSSMLC SVGASKAVFL WNMDKYTMIR KLEGHHHDVV ACDFSPDGAL LATASYDTRV YIWDPHNGDI LMEFGHLFPP PTPIFAGGAN DRWVRSVSFS HDGLHVASLA DDKMVRFWRI DEDYPVQVAP LSNGLCCAFS TDGSVLAAGT HDGSVYFWAT PRQVPSLQHL CRMSIRRVMP TQEVQELPIP SKLLEFLSYR I
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Molecular Weight
47.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WSB1, or "WD Repeat and SOCS Box Containing 1," is a protein that has garnered significant attention in recent years due to its multifaceted roles in various biological processes. The protein is known for its involvement in several cellular functions, including protein degradation, signal transduction, and transcription regulation. Recent studies suggest that WSB1 plays a critical role in modulating the activity of E3 ubiquitin ligases, which are essential for maintaining protein homeostasis in cells. Dysregulation of WSB1 has been implicated in a range of diseases, including cancer and neurodegenerative disorders, making it a potential target for therapeutic intervention. Furthermore, WSB1's interaction with other cellular proteins indicates its involvement in complex signaling pathways, which are crucial for cell growth, differentiation, and stress response. The investigation of WSB1's structure, function, and interaction networks is essential for understanding its role in health and disease. Researchers are particularly interested in elucidating the molecular mechanisms by which WSB1 exerts its effects, as this knowledge could lead to the development of novel treatments aimed at modulating its activity. Overall, the study of WSB1 is at the forefront of molecular biology and has the potential to provide insights into fundamental cellular processes and disease mechanisms.
