Analytical Data
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Gene name
WRB
- Application
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Alternative Names
GET1; CHD5; WRB; Guided entry of tail-anchored Proteins factor 1; Congenital heart disease 5 Protein; Tail-anchored Protein insertion receptor WRB; Tryptophan-rich basic Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00258
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Expression Region
1-174 aa
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AA Sequence
MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAEQESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKWVISVAFYVLQAALMISLIWKYYSVPVAVVPSKWITPLDRLVAFPTRVAGGVGITCWILVCNKVVAIVLHPFS
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Molecular Weight
46.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of WRB (waist region binding) recombinant proteins has gained significant attention in the field of molecular biology and biotechnology due to its potential applications in drug development and therapeutic interventions. WRB proteins are involved in crucial cellular processes, including protein folding and transport, which are essential for maintaining cellular homeostasis. Dysregulation of these processes is often associated with various diseases, including neurodegenerative disorders and cancer. Researchers have sought to elucidate the structure-function relationship of WRB proteins, which has led to advancements in recombinant DNA technology for the production of these proteins in genetically modified organisms. This allows for large-scale production and detailed functional studies, providing insight into their roles in cellular mechanisms. Moreover, the incorporation of WRB proteins into therapeutic strategies, such as targeted drug delivery systems and tissue engineering, underscores their importance. Ongoing investigations aim to enhance our understanding of WRB proteins' interactions and regulatory mechanisms, which could pave the way for innovative approaches in treating diseases linked to their dysfunction. Ultimately, the research on WRB recombinant proteins represents a vital intersection of biochemistry, genetics, and medical applications, holding promise for future therapeutic breakthroughs.
