Analytical Data
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基因名
DSCR6
- Application
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别名
RIPPLY3; DSCR6Protein ripply3; Down syndrome critical region protein 6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P57055
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表达区间
1-190aa
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氨基酸序列
MEPEAAAGARKARGRGCHCPGDAPWRPPPPRGPESPAPWRPWIQTPGDAELTRTGRPLEPRADQHTFGSKGAFGFQHPVRVYLPMSKRQEYLRSSGEQVLASFPVQATIDFYDDESTESASEAEEPEEGPPPLHLLPQEVGGRQENGPGGKGRDQGINQGQRSSGGGDHWGEGPLPQGVSSRGGKCSSSK
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分子量
46.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The DSCR6 protein, a member of the Down syndrome chromosomal region 6 (DSCR6) family, has garnered interest due to its potential implications in developmental biology and human health. Located on chromosome 21, DSCR6 is part of a region that is implicated in Down syndrome, a genetic disorder caused by trisomy of this chromosome. Research suggests that DSCR6 may play a crucial role in neuronal development and function, contributing to the cognitive and physical challenges associated with Down syndrome. Furthermore, studies have indicated that alterations in DSCR6 expression can impact cellular processes such as proliferation and apoptosis, raising questions about its role in oncogenesis. Investigating DSCR6's structure, function, and regulatory mechanisms is essential for understanding its biological significance, particularly in the context of developmental disorders and cancer. The modulation of DSCR6 has potential therapeutic implications, making it a target for studies aiming to mitigate the effects of Down syndrome and other related disorders. Overall, the exploration of DSCR6 is an important avenue in molecular biology, with far-reaching effects for both basic research and clinical applications.
