Analytical Data
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基因名
DSCR8
- Application
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别名
DSCR8; C21orf65; MTAG2Down syndrome critical region protein 8; Cancer/testis antigen 25; CT25; DCR1-24.0; Malignant melanoma-associated protein 1; MMA-1; Protein MTAG2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96T75
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表达区间
1-97aa
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氨基酸序列
MKEPGPNFVT VRKGLHSFKM AFVKHLLLFL SPRLECSGSI TDHCSLHLPV QEILMSQPPE QLGLQTNLGN QESSGMMKLF MPRPKVLAQY ESIQFMP
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分子量
10.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The DSCR8 protein, a member of the Down syndrome critical region (DSCR) gene cluster, has garnered significant attention in recent years due to its potential implications in both developmental biology and neurodegenerative diseases. The DSCR is located on chromosome 21 and is believed to play a crucial role in the phenotypic manifestations of Down syndrome. DSCR8, specifically, has been implicated in the regulation of gene expression and cellular processes critical for neuronal development and function. Researchers have noted its involvement in pathways associated with stress response, apoptosis, and cell cycle regulation, which are vital for maintaining cellular homeostasis. Furthermore, studies have suggested that DSCR8 might interact with various signaling pathways, including those impacting the Alzheimer's disease pathology, thereby highlighting its potential role in neuroprotection and neurodegeneration. As the scientific community seeks to unravel the precise functions of DSCR8, ongoing research aims to elucidate its molecular mechanisms and establish how it may contribute to both Down syndrome and broader neurological disorders. The understanding of DSCR8's role could pave the way for novel therapeutic strategies targeting conditions linked to chromosomal abnormalities and age-related cognitive decline.
