Analytical Data
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基因名
DSCR4
- Application
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别名
DCRB; Down syndrome critical region protein 4; Down syndrome critical region protein B; DSCR4; DSCR4_HUMAN; DSCRB
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56555
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表达区间
1-118aa
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氨基酸序列
MSLIILTRDDEPRIFTPDSDAASPALHSTSPLPDPASASPLHREEKILPKVCNIVSCLSFSLPASPTDSGLASPTIITREGQQFWAKCLIWKYQLYLHGLHKKSDGRRDKQISASPST
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The DSCR4 (Down syndrome critical region 4) protein is located within the chromosomal region 21q22.2, which is critical for understanding the pathophysiology of Down syndrome (DS), a genetic disorder caused by the presence of an extra copy of chromosome 21. Emerging research has highlighted DSCR4 as a candidate gene that may contribute to the phenotypic features observed in individuals with Down syndrome, including cognitive deficits and cardiac anomalies. DSCR4 is believed to play a role in cellular processes such as cell proliferation, apoptosis, and stress response, which are pertinent to Down syndrome's complex developmental and physiological challenges. Investigations into the structure and function of DSCR4 protein have revealed its potential involvement in neurodevelopmental pathways, making it a significant focus for studies aimed at deciphering the molecular mechanisms underpinning brain development and function in both typical and atypical contexts. Furthermore, the study of DSCR4 may provide insights into potential therapeutic strategies to mitigate the adverse effects of DS in affected individuals. As research continues to unravel the implications of DSCR4 in cellular and systemic contexts, it remains an essential target for further exploration in the quest to improve outcomes for those with Down syndrome. This ongoing investigation is expected to offer new avenues for understanding the intricate interplay of genetics, biology, and the environment in shaping the lives of individuals with this disorder.
