Analytical Data
-
基因名
SPRY1
- Application
-
别名
SPRY1；Protein sprouty homolog 1
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
O43609
-
表达区间
1-319aa
-
氨基酸序列
MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS NTVYCKLESC PSRGQGKPS
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SPRY1 is a member of the SPRY (sprouty) protein family, known for its role in regulating various signaling pathways, particularly in response to growth factors. Research has shown that SPRY1 plays a critical role in modulating cellular processes such as proliferation, differentiation, and migration, which are pivotal in development and cancer progression. The protein acts as a negative regulator of receptor tyrosine kinases (RTKs), helping to prevent excessive signaling that can lead to oncogenesis. Due to its involvement in key signaling pathways, SPRY1 has gained attention as a potential therapeutic target for cancer treatment and other diseases related to dysregulated cell signaling. Studies have demonstrated that SPRY1 can influence pathways such as MAPK/ERK and PI3K/Akt, making it a crucial player in tumor biology. Furthermore, understanding the molecular mechanisms underlying SPRY1's actions may provide insights into developing novel drugs or therapeutic strategies that can enhance or mimic its functions. Therefore, the characterization of recombinant SPRY1 protein is vital for elucidating its structure, function, and interaction with other cellular components, facilitating a deeper understanding of its role in health and disease. This research not only advances basic biological knowledge but also holds promise for translational applications in cancer therapeutics, highlighting the significance of SPRY1 as a focal point in cellular signaling studies.
