Analytical Data
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基因名
TAF1A
- Application
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别名
MGC:17061; RAFI48; RNA polymerase I-specific TBP-associated factor 48 kDa; SL1 48kD subunit; SL1; Taf1a; TAF1A_HUMAN; TAFI48; TATA box binding protein (TBP) associated factor RNA polymerase I. A 48kDa; TATA box binding protein (Tbp)-associated factor. RNA polymerase I. A; TATA box binding protein associated factor 1A; TATA box binding protein associated factor RNA polymerase I subunit A; TATA box-binding protein-associated factor 1A; TATA box-binding protein-associated factor RNA polymerase I subunit A; TBP associated factor RNA polymerase I 48 kDa; TBP-associated factor 1A; Transcription factor SL1; Transcription initiation factor SL1/TIF-IB subunit A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15573
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表达区间
1-450 aa
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氨基酸序列
MSDFSEELKG PVTDDEEVET SVLSGAGMHF PWLQTYVETV AIGGKRRKDF AQTTSACLSF IQEALLKHQW QQAAEYMYSY FQTLEDSDSY KRQAAPEIIW KLGSEILFYH PKSNMESFNT FANRMKNIGV MNYLKISLQH ALYLLHHGML KDAKRNLSEA ETWRHGENTS SREILINLIQ AYKGLLQYYT WSEKKMELSK LDKDDYAYNA VAQDVFNHSW KTSANISALI KIPGVWDPFV KSYVEMLEFY GDRDGAQEVL TNYAYDEKFP SNPNAHIYLY NFLKRQKAPR SKLISVLKIL YQIVPSHKLM LEFHTLLRKS EKEEHRKLGL EVLFGVLDFA GCTKNITAWK YLAKYLKNIL MGNHLAWVQE EWNSRKNWWP GFHFSYFWAK SDWKEDTALA CEKAFVAGLL LGKGCRYFRY ILKQDHQILG KKIKRMKRSV KKYSIVNPRL
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分子量
52.6kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAF1A (TATA-binding protein associated factor 1A) is a crucial component of the transcriptional machinery, playing a significant role in the regulation of gene expression. It is part of the larger TAF (TATA-binding protein-associated factor) complex, which is essential for RNA polymerase II-mediated transcription. Research into TAF1A has gained importance due to its involvement in various cellular processes and its potential link to several diseases, including cancer. High expression levels of TAF1A have been correlated with increased proliferation and invasiveness of tumor cells, suggesting its role as a potential oncogene. Moreover, TAF1A is known to interact with various proteins and transcription factors, influencing chromatin remodeling and gene activation. The recombinant production of TAF1A protein allows for in-depth functional studies, aiding in the understanding of its mechanisms in transcriptional regulation and its contributions to disease pathology. By utilizing advanced biotechnological strategies, researchers aim to elucidate the functional properties of TAF1A, explore its interactions with other cellular components, and assess its potential as a therapeutic target in cancer and other disorders.
