Analytical Data
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Gene name
WDR51B
- Application
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Alternative Names
4933430F16Rik; FLJ14923; FLJ41111; Pix1; POC1 centriolar Protein homolog B (Chlamydomonas); POC1 centriolar Protein homolog B; POC1B; POC1B_HUMAN; TUWD12; WD repeat containing Protein 51B; WD repeat domain 51B; WD repeat-containing Protein 51B; WDR51B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TC44
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Expression Region
1-478 aa
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AA Sequence
MASATEDPVL ERYFKGHKAA ITSLDLSPNG KQLATASWDT FLMLWNFKPH ARAYRYVGHK DVVTSVQFSP HGNLLASASR DRTVRLWIPD KRGKFSEFKA HTAPVRSVDF SADGQFLATA SEDKSIKVWS MYRQRFLYSL YRHTHWVRCA KFSPDGRLIV SCSEDKTIKI WDTTNKQCVN NFSDSVGFAN FVDFNPSGTC IASAGSDQTV KVWDVRVNKL LQHYQVHSGG VNCISFHPSG NYLITASSDG TLKILDLLEG RLIYTLQGHT GPVFTVSFSK GGELFASGGA DTQVLLWRTN FDELHCKGLT KRNLKRLHFD SPPHLLDIYP RTPHPHEEKV ETVEINPKLE VIDLQISTPP VMDILSFDST TTTETSGRTL PDKGEEACGY FLNPSLMSPE CLPTTTKKKT EDMSDLPCES QRSIPLAVTD ALEHIMEQLN VLTQTVSILE QRLTLTEDKL KDCLENQQKL FSAVQQKS
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Molecular Weight
53.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR51B, a member of the WD-repeat protein family, has garnered attention in recent years due to its potential roles in cellular processes such as DNA repair, cell cycle regulation, and gene expression. Preliminary studies suggest that WDR51B may be involved in homologous recombination, a crucial mechanism for DNA repair that ensures genome stability. Notably, mutations or dysregulation of WDR51B expression have been linked to various cancer types, which raises the possibility of this protein as a biomarker for cancer prognosis or a potential target for therapeutic intervention. As a result, researchers are focused on producing recombinant WDR51B protein to investigate its structure and function in vitro. By utilizing techniques such as molecular cloning, protein expression systems, and biochemical assays, scientists aim to elucidate the mechanistic role of WDR51B in DNA damage response pathways. Understanding the precise functions of WDR51B not only enhances our comprehension of fundamental cellular processes but may also unveil novel strategies for cancer treatment. As such, the study of this recombinant protein represents a vital step toward exploring its functional significance and therapeutic potential in oncology.
