Analytical Data
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基因名
WDR51A
- Application
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别名
POC1 centriolar Protein homolog A. Pix2. Proteome of centriole Protein 1A. WD repeat-containing Protein 51A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NBT0
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表达区间
1-364 aa
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氨基酸序列
MVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP
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分子量
65.78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR51A, a member of the WD repeat-containing protein family, has garnered significant attention in recent years due to its critical role in various cellular processes, particularly in DNA repair and cell cycle regulation. Research indicates that WDR51A is involved in homologous recombination, a key mechanism that ensures genomic stability by repairing double-strand breaks in DNA. Mutations or dysregulation of WDR51A have been implicated in several cancers, highlighting its potential as a biomarker and therapeutic target. Studies show that WDR51A interacts with several key proteins involved in the DNA damage response, suggesting that its activity is essential for maintaining genomic integrity. Moreover, the functional characterization of WDR51A through recombinant protein studies aids in understanding its biochemical properties and interactions at a molecular level, paving the way for novel approaches in cancer therapy and precision medicine. Thus, the exploration of WDR51A's functions and mechanisms not only sheds light on fundamental biological processes but also holds promise for advancing therapeutic strategies against cancer.
