Analytical Data
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基因名
WDR4
- Application
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别名
OTTHUMP00000109401; OTTHUMP00000109402; TRM82; tRNA (guanine N(7) ) methyltransferase subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4; WD repeat containing Protein 4; WD repeat Protein 4; WD repeat Protein domain 4 Protein isoform 2; WD repeat-containing Protein 4; wdr4; WDR4_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P57081
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表达区间
2-412 aa
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氨基酸序列
AGSVGLALCGQTLVVRGGSRFLATSIASSDDDSLFIYDCSAAEKKSQENKGEDAPLDQGS GAILASTFSKSGSYFALTDDSKRLILFRTKPWQCLSVRTVARRCTALTFIASEEKVLVAD KSGDVYSFSVLEPHGCGRLELGHLSMLLDVAVSPDDRFILTADRDEKIRVSWAAAPHSIE SFCLGHTEFVSRISVVPTQPGLLLSSSGDGTLRLWEYRSGRQLHCCHLASLQELVDPQAP QKFAASRIAFWCQENCVALLCDGTPVVYIFQLDARRQQLVYRQQLAFQHQVWDVAFEETQ GLWVLQDCQEAPLVLYRPVGDQWQSVPESTVLKKVSGVLRGNWAMLEGSAGADASFSSLY KATFDNVTSYLKKKEERLQQQLEKKQRRRSPPPGPDGHAKKMRPGEATLSC
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分子量
45.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR4, or WD repeat-containing protein 4, is a critical component involved in various cellular processes, including RNA processing, gene regulation, and chromatin remodeling. Its role in the assembly of multiprotein complexes has made it a focal point of research in understanding fundamental biological mechanisms. Studies have shown that WDR4 is integral to the function of the SLBP (Stem-Loop Binding Protein) in histone mRNA processing and contributes to the expression of genes related to cell proliferation and differentiation. Dysregulation of WDR4 has been implicated in several diseases, particularly cancer, where alterations in its expression can influence tumor growth and metastasis. Given the importance of WDR4 in essential cellular functions and its potential link to disease, researchers aim to better understand its structure and function through the production of recombinant WDR4 protein. This approach facilitates in-depth studies of its interactions with other proteins and its role in cellular pathways. By elucidating the molecular mechanisms associated with WDR4, scientists hope to uncover new therapeutic targets and develop strategies for treating diseases associated with its dysfunction. The ongoing investigation into WDR4's properties and its implications in health and disease underscores its significance in molecular biology and biomedical research.
