Analytical Data
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基因名
SYNE2
- Application
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别名
DKFZP434H2235; DKFZp686E01115; DKFZp686H1931; FLJ11014; FLJ43727; FLJ45710; FLJ46790; KIAA1011; Nesprin-2; Nesprin2; NUA; NUANCE; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element; Nucleus and actin connecting element protein; Protein NUANCE; Spectrin repeat containing nuclear envelope 2; Synaptic nuclear envelope protein 2; Synaptic nuclei expressed gene 2; SYNE 2; Syne-2; SYNE2; SYNE2_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WXH0
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表达区间
6702 -6799 aa
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氨基酸序列
CRRELMQLEKELVERQPQVDMLQEISNSLLIKGHGEDCIEAEEKVHVIEKKLKQLREQVSQDLMALQGTQNPASPLPSFDEVDSGDQPPATSVPAPRA
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分子量
36.52kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SYNE2, also known as Synemin 2, is a member of the spectrin repeat-containing superfamily, which plays a crucial role in maintaining the structure and mechanical integrity of the cell nucleus and cytoskeleton. It is primarily expressed in various tissues, particularly in muscle and neuronal cells, where it contributes to cellular architecture and mechanotransduction. Research on SYNE2 has gained momentum due to its implications in several physiological and pathological processes, including muscle development, neuronal signaling, and its potential association with various diseases such as muscular dystrophies and neurodegenerative disorders. The study of SYNE2 recombinant proteins offers valuable insights into its functional dynamics, interactions with other cytoskeletal components, and the molecular mechanisms underlying its role in health and disease. By expressing and purifying SYNE2 as a recombinant protein, researchers aim to elucidate its structure-function relationships, explore its interactions with binding partners, and develop therapeutic strategies targeting SYNE2-related pathologies. This research is pivotal for advancing our understanding of cytoskeletal organization and its implications in cellular mechanics, ultimately guiding the development of targeted interventions for related diseases.
