Analytical Data
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基因名
WDR23
- Application
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别名
DCAF11; WDR23; GL014; PRO2389DDB1- and CUL4-associated factor 11; WD repeat-containing Protein 23
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TEB1
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表达区间
1-546 aa
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氨基酸序列
MGSRNSSSAG SGSGDPSEGL PRRGAGLRRS EEEEEEDEDV DLAQVLAYLL RRGQVRLVQG GGAANLQFIQ ALLDSEEEND RAWDGRLGDR YNPPVDATPD TRELEFNEIK TQVELATGQL GLRRAAQKHS FPRMLHQRER GLCHRGSFSL GEQSRVISHF LPNDLGFTDS YSQKAFCGIY SKDGQIFMSA CQDQTIRLYD CRYGRFRKFK SIKARDVGWS VLDVAFTPDG NHFLYSSWSD YIHICNIYGE GDTHTALDLR PDERRFAVFS IAVSSDGREV LGGANDGCLY VFDREQNRRT LQIESHEDDV NAVAFADISS QILFSGGDDA ICKVWDRRTM REDDPKPVGA LAGHQDGITF IDSKGDARYL ISNSKDQTIK LWDIRRFSSR EGMEASRQAA TQQNWDYRWQ QVPKKAWRKL KLPGDSSLMT YRGHGVLHTL IRCRFSPIHS TGQQFIYSGC STGKVVVYDL LSGHIVKKLT NHKACVRDVS WHPFEEKIVS SSWDGNLRLW QYRQAEYFQD DMPESEECAS APAPVPQSST PFSSPQ
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分子量
61.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR23, a member of the WD40 repeat protein family, has garnered attention in recent years due to its critical role in cellular processes, particularly in protein degradation and regulatory mechanisms. This protein functions as a substrate adaptor for the cullin-RING ligase (CRL) complex, which is integral to the ubiquitin-proteasome system that facilitates the controlled degradation of proteins, thus maintaining cellular homeostasis and influencing various biological pathways. Research indicates that WDR23 is involved in modulating cellular responses to stress and may have implications in developmental processes and disease states, including cancer. Its interactions with multiple signaling pathways accentuate its importance in regulating gene expression and cellular function. Given its pivotal role, understanding the structure and function of WDR23 is essential for exploring its potential as a therapeutic target for diseases associated with dysregulated protein degradation and signaling. Current studies focus on the characterization of WDR23's interactions at the molecular level, the implications of its dysregulation, and the development of recombinant forms to probe its biological functions and mechanisms of action in vitro and in vivo.
