Analytical Data
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基因名
MYC
- Application
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别名
MYC；BHLHE39；Myc proto-oncogene Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01106-2
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表达区间
1-454aa
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氨基酸序列
MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQ QQSELQPPAPSEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTPFSLRGD NDGGGGSFSTADQLEMVTELLGGDMVNQSFICDPDDETFIKNIIIQDCMW SGFSAAAKLVSEKLASYQAARKDSGSPNPARGHSVCSTSSLYLQDLSAAA SECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLLSSTESSPQGSP EPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSAG GHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQ ISNNRKCTSPRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELE NNEKAPKVVILKKATAYILSVQAEEQKLISEEDLLRKRREQLKHKLEQLR NSCAESGGGGSPGRRRRRRRRRRR
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分子量
53 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MYC protein, a crucial transcription factor, plays a significant role in regulating cell proliferation, growth, and metabolism. Aberrant expression of MYC is frequently associated with various types of cancers, making it a focal point for oncogenetic research. Historically, MYC was first identified in the context of the Burkitt lymphoma, and since then, its implications have expanded to encompass a wide range of malignancies, including breast, colon, and lung cancers. The MYC protein functions by binding to DNA and modulating gene expression, influencing processes such as cellular survival and apoptosis. Given its pivotal role in cancer biology, the study of MYC and its signaling pathways has garnered considerable attention, leading to the exploration of MYC as a therapeutic target. Researchers have been investigating the development of MYC inhibitors and recombinant MYC proteins to better understand its functionality and interaction with various cellular components. Furthermore, the production of recombinant MYC proteins allows for detailed biochemical characterization, which can elucidate its regulatory mechanisms and inform the design of targeted therapies. As such, the focus on recombinant MYC proteins not only enhances our comprehension of MYC's role in cancer but also paves the way for innovative strategies aimed at modulating its activity for therapeutic benefits in oncology.
