Analytical Data
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Gene name
SURF6
- Application
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Alternative Names
SURF-6; surf6; SURF6_HUMAN; Surfeit locus protein 6
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75683
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Expression Region
1-361 aa
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AA Sequence
MASLLAKDAY LQSLAKKICS HSAPEQQART RAGKTQGSET AGPPKKKRKK TQKKFRKREE KAAEHKAKSL GEKSPAASGA RRPEAAKEEA AWASSSAGNP ADGLATEPES VFALDVLRQR LHEKIQEARG QGSAKELSPA ALEKRRRRKQ ERDRKKRKRK ELRAKEKARK AEEATEAQEV VEATPEGACT EPREPPGLIF NKVEVSEDEP ASKAQRRKEK RQRVKGNLTP LTGRNYRQLL ERLQARQSRL DELRGQDEGK AQELEAKMKW TNLLYKAEGV KIRDDERLLQ EALKRKEKRR AQRQRRWEKR TAGVVEKMQQ RQDRRRQNLR RKKAARAERR LLRARKKGRI LPQDLERAGL V
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Molecular Weight
41.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SURF6 is a highly conserved protein that plays a crucial role in ribosome biogenesis and the assembly of ribosomal RNA and proteins into functional ribosomes. Initially identified in studies related to cell growth and proliferation, SURF6 has garnered interest due to its potential involvement in various cellular processes and diseases, including cancer. Research has shown that SURF6 interacts with several key ribosomal and non-ribosomal proteins, suggesting it may serve as a regulatory factor in the ribosome assembly pathway. Additionally, aberrations in SURF6 expression and function have been correlated with various malignancies, leading to investigations into its role as a potential biomarker or therapeutic target. The focus of recent studies has centered on elucidating the mechanism by which SURF6 contributes to ribosome biogenesis and its influence on cellular stress responses. Understanding SURF6's function could provide insights into the fundamental molecular mechanisms underlying translation and protein synthesis, as well as reveal novel pathways that may be exploited for therapeutic intervention in diseases characterized by dysregulated protein synthesis. Thus, the ongoing research on SURF6 recombinant protein is not only significant for fundamental biology but also for its implications in disease mechanisms and potential treatments.
