Analytical Data
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Gene name
WDR19
- Application
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Alternative Names
DYF 2; DYF2; FLJ23127; IFT144; Intraflagellar transport 144 homolog; KIAA1638; ORF26; Oseg6; PWDMP; WD repeat containing Protein 19; WD repeat domain 19; WD repeat membrane Protein PWDMP; WD repeat-containing Protein 19; Wdr19; WDR19_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NEZ3
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Expression Region
1-437 aa
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AA Sequence
MKRIFSLLEKTWLGAPIQFAWQKTSGNYLAVTGADYIVKIFDRHGQKRSEINLPGNCVAMDWDKDGDVLAVIAEKSSCIYLWDANTNKTSQLDNGMRDQMSFLLWSKVGSFLAVGTVKGNLLIYNHQTSRKIPVLGKHTKRITCGCWNAENLLALGGEDKMITVSNQEGDTIRQTQVRSEPSNMQFFLMKMDDRTSAAESMISVVLGKKTLFFLNLNEPDNPADLEFQQDFGNIVCYNWYGDGRIMIGFSCGHFVVISTHTGELGQEIFQARNHKDNLTSIAVSQTLNKVATCGDNCIKIQDLVDLKDMYVILNLDEENKGLGTLSWTDDGQLLALSTQRGSLHVFLTKLPILGDACSTRIAYLTSLLEVTVANPVEGELPITVSVDVEPNFVAVGLYHLAVGMNNRAWFYVLGENAVKKIERYGVSGNSSQYLPSF
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Molecular Weight
75 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR19, a member of the WD-repeat protein family, has garnered significant attention in biomedical research due to its essential role in various cellular processes, including ciliary function and cell signaling pathways. Recent studies have highlighted its involvement in the pathogenesis of ciliopathies, a group of disorders resulting from dysfunctional cilia, which can lead to severe developmental and metabolic abnormalities. The reconstitution of WDR19 as a recombinant protein allows for detailed investigations into its structural and functional properties, which are critical for understanding its mechanistic role in ciliary assembly and maintenance. This research is vital, as mutations in the WDR19 gene have been linked to conditions such as primary ciliary dyskinesia (PCD) and other syndromic ciliopathies. By studying WDR19 in a controlled laboratory environment, scientists aim to elucidate its interactions with other ciliary proteins and to define its specific contributions to cilia-related signaling pathways. Ultimately, these insights may not only clarify the molecular underpinnings of WDR19-related diseases but also pave the way for potential therapeutic approaches targeted at mitigating the effects of ciliary dysfunction. Understanding WDR19's biological significance could lead to enhanced diagnostic strategies and treatment options for patients affected by ciliopathies, underscoring its relevance in modern medical research.
