Analytical Data
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基因名
SULT1C3
- Application
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别名
SULT1C3; Sulfotransferase 1C3; ST1C3; EC 2.8.2.2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6IMI6
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表达区间
1-304 aa
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氨基酸序列
MAKIEKNAPT MEKKPELFNI MEVDGVPTLI LSKEWWEKVC NFQAKPDDLI LATYPKSGTT WMHEILDMIL NDGDVEKCKR AQTLDRHAFL ELKFPHKEKP DLEFVLEMSS PQLIKTHLPS HLIPPSIWKE NCKIVYVARN PKDCLVSYYH FHRMASFMPD PQNLEEFYEK FMSGKVVGGS WFDHVKGWWA AKDMHRILYL FYEDIKKDPK REIEKILKFL EKDISEEILN KIIYHTSFDV MKQNPMTNYT TLPTSIMDHS ISPFMRKGMP GDWKNYFTVA QNEEFDKDYQ KKMAGSTLTF RTEI
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分子量
35.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SULT1C3, a member of the sulfotransferase family, plays a crucial role in the biotransformation of various endogenous and exogenous compounds through the process of sulfonation, which generally enhances their solubility and facilitates their excretion. This enzyme is particularly important in the metabolism of steroid hormones, neurotransmitters, and certain drugs, thereby influencing pharmacokinetics and toxicology. Research into SULT1C3 has intensified due to its potential implications in drug metabolism and individual variations in drug response, which can lead to adverse drug reactions or ineffective treatments. The recombinant expression of SULT1C3 protein is vital for understanding its biochemical properties, substrate specificity, and catalytic mechanisms. Furthermore, studying the structural characteristics of the SULT1C3 protein through crystallography and other biophysical methods can provide insights into its functional roles in different physiological contexts. Additionally, the investigation of polymorphisms and regulatory mechanisms that affect SULT1C3 expression may offer valuable information regarding interindividual variability in drug metabolism. Overall, the exploration of SULT1C3 recombinant protein not only contributes to our understanding of pharmacogenomics but also has the potential to inform the development of new therapeutic strategies tailored to individual metabolic profiles.
