Analytical Data
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Gene name
VPS26B
- Application
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Alternative Names
Pep8b; Vacuolar Protein sorting 26 homolog B (S. pombe); Vacuolar Protein sorting 26 homolog B (yeast); Vacuolar Protein sorting-associated Protein 26B; Vesicle Protein sorting 26B; VP26B_HUMAN; VPS26B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q4G0F5
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Expression Region
1-336 aa
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AA Sequence
MSFFGFGQSV EVEILLNDAE SRKRAEHKTE DGKKEKYFLF YDGETVSGKV SLALKNPNKR LEHQGIKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIT QSQAFDFEFT HVEKPYESYT GQNVKLRYFL RATISRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEV VLWRKGDIVR KSMSHQAAIA SQRFEGTTSL GEVRTPSQLS DNNCRQ
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Molecular Weight
39.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS26B, a member of the retromer complex, plays a crucial role in intracellular trafficking and the maintenance of protein homeostasis. It is involved in the retrieval of transmembrane proteins from endosomes back to the Golgi apparatus, which is essential for recycling and the proper functioning of various cellular pathways. Recent studies have highlighted the significance of VPS26B in neurodegenerative diseases, as mutations can disrupt its function and contribute to protein misfolding and aggregation. Furthermore, VPS26B is highly expressed in the brain, indicating its potential role in neuronal health and development. Understanding the mechanisms by which VPS26B operates and how it interacts with other proteins involved in the endosomal-lysosomal pathway is critical for developing therapeutic strategies aimed at mitigating the effects of its dysfunction. Research on VPS26B recombinant proteins has also opened avenues for exploring its structure-function relationship, providing insight into how post-translational modifications may influence its activity. As studies continue to unveil the complexities of VPS26B's role in cellular processes, this research could pave the way for advancements in treating conditions associated with its impaired function, including Alzheimer's disease and other forms of neurodegeneration.
