Analytical Data
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Gene name
DMRTA2
- Application
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Alternative Names
DMRTA2; DMRT5Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related transcription factor 5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96SC8
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Expression Region
1-542aa
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AA Sequence
MELRSELPSV PGAATAAAAT ATGPPVASVA SVAAAAAAAA SLPVSVAGGL LRGPPLLLRA AEKYPRTPKC ARCRNHGVVS ALKGHKRYCR WKDCLCAKCT LIAERQRVMA AQVALRRQQA QEENEARELQ LLYGTAEGLA LAAANGIIPP RPAYEVFGSV CAADGGGPGA GAPAGTGGGA AGAGGSEAKL QKFDLFPKTL LQAGRPGSPL PPPVKPLSPD GADSGPGTSS PEVRPGSGSE NGDGESFSGS PLARASKEAG GSCPGSAGPG GGGEEDSPGS ASPLGSESGS EADKEEGEAA PAPGLGGGSG PRQRTPLDIL TRVFPGHRRG VLELVLQGCG GDVVQAIEQV LNHHRGGLAA GLGPAAPPDK AAVGAAAAAD DAWPSRVDAA AAAAAAAGGP GLPAPLQAGP AAPPHHRPLL AGAMAPGALG SLSSRSAFSP LQPNASHFGA DAGAYPLGAP LGLSPLRLAY SAAAAHSRGL AFMAPYSTAG LVPTLGFRPP MDYAFSDLMR DRSAAAAAAV HKEPTYGGGL YGPMVNGAPE KQ
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Molecular Weight
53.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The DMRTA2 protein, a member of the DMRT (Doublesex and Mab-3 Related Transcription factor) family, plays a crucial role in sexual differentiation and gonadal development across various species. Studies have shown that DMRTA2 is involved in the regulation of key genes pertinent to reproductive biology, influencing processes such as spermatogenesis and ovarian function. Its expression patterns are tightly linked to the development of the reproductive system, with specific roles identified in both males and females. Recent research has highlighted the importance of DMRTA2 in maintaining stem cell populations in the gonads and its potential implications in disorders of sex development. As a transcription factor, DMRTA2 also interacts with various signaling pathways, modulating the expression of downstream targets essential for normal reproductive function. Understanding the molecular mechanisms of DMRTA2 can provide insights into its role in fertility issues and its potential as a biomarker for reproductive health. Given the evolutionary conservation of DMRT family members, studies of DMRTA2 not only enhance our knowledge of vertebrate sex determination and differentiation but also offer potential avenues for developing therapeutic strategies in reproductive medicine.
