Analytical Data
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Gene name
PAK2
- Application
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Alternative Names
PAK2；Serine/threonine-Protein kinase PAK 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13177
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Expression Region
2-524aa
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AA Sequence
SDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTEAPAVVTE EEDDDEETAP PVIAPRPDHT KSIYTRSVID PVPAPVGDSH VDGAAKSLDK QKKKTKMTDE EIMEKLRTIV SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAK2, or p21-activated kinase 2, is a serine/threonine protein kinase that plays a pivotal role in various cellular processes, including cytoskeletal reorganization, cell motility, and survival signals. As a member of the PAK family, PAK2 is activated by small GTPases such as Cdc42 and Rac, linking external signals to intracellular responses. Dysregulation of PAK2 has been implicated in several pathological conditions, including cancer, where it contributes to tumor growth and metastasis, making it a potential target for therapeutic intervention. Research into PAK2 recombinant protein is crucial for elucidating its biological functions and understanding its mechanistic roles in cellular signaling pathways. By producing PAK2 as a recombinant protein, scientists can investigate its enzymatic activity, interaction with other proteins, and impact on cellular pathways in a controlled experimental setting. Furthermore, the development of specific inhibitors or modulators targeting PAK2 could lead to novel strategies for treating diseases associated with its aberrant activation. In summary, studying PAK2 recombinant protein provides valuable insights into its function and regulation, highlighting its significance in health and disease and establishing a foundation for potential therapeutic advancements.
