Analytical Data
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Gene name
DHRS3
- Application
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Alternative Names
DHRS3; RDH17; SDR16C1; UNQ2424/PRO4983; Short-chain dehydrogenase/reductase 3; DD83.1; Retinal short-chain dehydrogenase/reductase 1; retSDR1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75911
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Expression Region
1-302aa
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AA Sequence
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
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Molecular Weight
59.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DHRS3 (Dehydrogenase/Reductase 3) is a member of the short-chain dehydrogenase/reductase (SDR) family, known for its role in various metabolic processes. Research on DHRS3 has gained momentum due to its involvement in the metabolism of retinoids and steroid hormones, which are critical for numerous physiological functions including vision, reproduction, and cellular signaling. Dysregulation of DHRS3 expression has been linked to several diseases, including cancer and metabolic disorders, making it a potential biomarker and therapeutic target. Studies have also suggested that DHRS3 may play a role in the response to oxidative stress, leading to interest in its function in cellular protection mechanisms. Advances in recombinant protein technology have enabled the production of DHRS3 in heterologous systems, facilitating detailed investigations into its enzymatic activity, structural features, and interactions with various substrates and inhibitors. Understanding the structure-function relationship of DHRS3 is crucial for elucidating its biological roles and potential therapeutic applications, thus driving research aimed at characterizing this enzyme's kinetic parameters, regulatory mechanisms, and the impact of genetic variations on its function. This knowledge could pave the way for innovative strategies in disease intervention and metabolic engineering.
