Analytical Data
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基因名
DHRS3
- Application
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别名
DHRS3; RDH17; SDR16C1; UNQ2424/PRO4983; Short-chain dehydrogenase/reductase 3; DD83.1; Retinal short-chain dehydrogenase/reductase 1; retSDR1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75911
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表达区间
1-302aa
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氨基酸序列
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
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分子量
59.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DHRS3 (Dehydrogenase/Reductase 3) is a member of the short-chain dehydrogenase/reductase (SDR) family, known for its role in various metabolic processes. Research on DHRS3 has gained momentum due to its involvement in the metabolism of retinoids and steroid hormones, which are critical for numerous physiological functions including vision, reproduction, and cellular signaling. Dysregulation of DHRS3 expression has been linked to several diseases, including cancer and metabolic disorders, making it a potential biomarker and therapeutic target. Studies have also suggested that DHRS3 may play a role in the response to oxidative stress, leading to interest in its function in cellular protection mechanisms. Advances in recombinant protein technology have enabled the production of DHRS3 in heterologous systems, facilitating detailed investigations into its enzymatic activity, structural features, and interactions with various substrates and inhibitors. Understanding the structure-function relationship of DHRS3 is crucial for elucidating its biological roles and potential therapeutic applications, thus driving research aimed at characterizing this enzyme's kinetic parameters, regulatory mechanisms, and the impact of genetic variations on its function. This knowledge could pave the way for innovative strategies in disease intervention and metabolic engineering.
