Analytical Data
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Gene name
RAD23B
- Application
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Alternative Names
RAD23B；UV excision repair Protein RAD23 homolog B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P54727
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Expression Region
1-409aa
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AA Sequence
MQVTLKTLQQ QTFKIDIDPE ETVKALKEKI ESEKGKDAFP VAGQKLIYAG KILNDDTALK EYKIDEKNFV VVMVTKPKAV STPAPATTQQ SAPASTTAVT SSTTTTVAQA PTPVPALAPT STPASITPAS ATASSEPAPA SAAKQEKPAE KPAETPVATS PTATDSTSGD SSRSNLFEDA TSALVTGQSY ENMVTEIMSM GYEREQVIAA LRASFNNPDR AVEYLLMGIP GDRESQAVVD PPQAASTGAP QSSAVAAAAA TTTATTTTTS SGGHPLEFLR NQPQFQQMRQ IIQQNPSLLP ALLQQIGREN PQLLQQISQH QEHFIQMLNE PVQEAGGQGG GGGGGSGGIA EAGSGHMNYI QVTPQEKEAI ERLKALGFPE GLVIQAYFAC EKNENLAANF LLQQNFDED
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RAD23B is a member of the RAD23 protein family, which plays a crucial role in DNA repair and cellular responses to genotoxic stress. This protein is involved in the regulation of the nucleotide excision repair (NER) pathway, facilitating the recognition and repair of DNA lesions caused by UV radiation and other environmental agents. RAD23B functions by interacting with various proteins implicated in the DNA repair process, thereby enhancing their stability and activity. Additionally, RAD23B has been shown to participate in the cross-talk between DNA repair mechanisms and protein degradation pathways, particularly the ubiquitin-proteasome system, which is essential for maintaining genome integrity. Research has indicated that alterations in RAD23B expression or function may be linked to various human diseases, including cancer, where impaired DNA repair can lead to genomic instability. Thus, understanding the molecular mechanisms and interactions of RAD23B is pivotal for elucidating its role in maintaining cellular homeostasis and developing potential therapeutic strategies targeting DNA repair pathways. The study of RAD23B recombinant protein can provide insights into its biochemical properties and functions, revealing its potential as a biomarker or therapeutic target in oncology and other fields related to DNA damage responses.
