Analytical Data
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基因名
BCL11B
- Application
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别名
BCL11B；CTIP2；RIT1；B-cell lymphoma/leukemia 11B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9C0K0
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表达区间
387-823aa
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氨基酸序列
QLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEPGTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDSELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAERS
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分子量
53.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BCL11B, a member of the BCL-2 family of proteins, plays a critical role in the development and function of various cell types, particularly in the immune system and the central nervous system. Research has indicated that BCL11B is essential for the differentiation of T-lineage cells and is involved in the regulation of gene expression during hematopoiesis. Mutations and dysregulation in BCL11B have been linked to a range of disorders, including immunodeficiencies and neurological diseases. The study of BCL11B recombinant proteins is important for understanding its structural and functional properties, which can provide insights into its role in disease mechanisms. Furthermore, exploring BCL11B interactions with other proteins and DNA may reveal potential therapeutic targets for the treatment of related conditions. The generation of BCL11B recombinant proteins allows for detailed biochemical and biophysical characterization, facilitating the exploration of its therapeutic potential, as well as its role in physiological and pathological processes. Overall, the ongoing research on BCL11B is critical for elucidating its function in various biological contexts and could lead to significant advancements in the understanding and treatment of related diseases.
