Analytical Data
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Gene name
SOCS7
- Application
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Alternative Names
Ash and phospholipase C gamma-binding protein; NAP 4; NAP 4 Fragment; NAP-4; NAP4; Nck; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; Nck-associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS-7; SOCS4; SOCS6; Socs7; SOCS7_HUMAN; Suppressor of cytokine signaling 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O14512
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Expression Region
1-581 aa
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AA Sequence
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL ESEAESLETN SCSEEELSSP GRGGGGGGRL LLQPPGPELP PVPFPLQDLV PLGRLSRGEQ QQQQQQQPPP PPPPPGPLRP LAGPSRKGSF KIRLSRLFRT KSCNGGSGGG DGTGKRPSGE LAASAASLTD MGGSAGRELD AGRKPKLTRT QSAFSPVSFS PLFTGETVSL VDVDISQRGL TSPHPPTPPP PPRRSLSLLD DISGTLPTSV LVAPMGSSLQ SFPLPPPPPP HAPDAFPRIA PIRAAESLHS QPPQHLQCPL YRPDSSSFAA SLRELEKCGW YWGPMNWEDA EMKLKGKPDG SFLVRDSSDP RYILSLSFRS QGITHHTRME HYRGTFSLWC HPKFEDRCQS VVEFIKRAIM HSKNGKFLYF LRSRVPGLPP TPVQLLYPVS RFSNVKSLQH LCRFRIRQLV RIDHIPDLPL PKPLISYIRK FYYYDPQEEV YLSLKEAQLI SKQKQEVEPS T
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Molecular Weight
62.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SOCS7 (Suppressor of Cytokine Signaling 7) is a member of the SOCS protein family, which is known for its role in regulating cytokine signaling pathways. The SOCS proteins, including SOCS7, act as negative feedback regulators of various signaling pathways, particularly those involved in inflammatory responses and immune regulation. Previous studies have indicated that SOCS7 may play a crucial role in modulating glucose metabolism and insulin signaling, highlighting its potential implications in metabolic disorders like obesity and diabetes. Additionally, SOCS7 has been linked to processes such as cell proliferation and differentiation, suggesting a broader role in development and disease. Research on SOCS7 recombinant proteins aims to elucidate its functional role, interactions with other signaling molecules, and potential therapeutic targets. Understanding the molecular mechanisms by which SOCS7 regulates signaling pathways may provide insights into developing novel treatments for diseases characterized by dysregulated cytokine signaling, such as autoimmune disorders and cancer. Given the increasing prevalence of metabolic diseases and the complexity of cytokine networks, investigating SOCS7 may reveal critical therapeutic avenues and enhance our understanding of cellular homeostasis and immune responses.
